Changes and Clinical Value of Serum miR-24 and miR-223 Levels in Patients with Severe Pneumonia

Lin Gao; Qindi Liu; Weiwei Zhang; Hong Sun; Zhiming Kuang; Guangping Zhang; Zhenfei Huang

doi:10.2147/IJGM.S411966

Changes and Clinical Value of Serum miR-24 and miR-223 Levels in Patients with Severe Pneumonia

Int J Gen Med. 2023 Aug 28:16:3797-3804. doi: 10.2147/IJGM.S411966. eCollection 2023.

Authors

Lin Gao¹, Qindi Liu², Weiwei Zhang¹, Hong Sun¹, Zhiming Kuang¹, Guangping Zhang¹, Zhenfei Huang¹

Affiliations

¹ Department of Intensive Care Unit, Ganzhou People's Hospital, Ganzhou City, Jiangxi Province, 341000, People's Republic of China.
² Department of Respiratory and Critical Medicine, Ganzhou Fifth People's Hospital, Ganzhou City, Jiangxi Province, 341000, People's Republic of China.

Abstract

Introduction: Severe pneumonia progresses rapidly, so early assessment of the severity and prognosis is crucial for reducing mortality rates.

Objective: We explore the role of serum microRNA-24 (miR-24) and microRNA-223 (miR-223) in the prognosis of severe pneumonia.

Methods: There were a total of 96 patients with general pneumonia, 94 patients with severe pneumonia, and 93 healthy people, who were enrolled in this study. The levels of serum miR-24 and miR-223 were detected by real-time fluorescent quantitative PCR in all groups.

Results: The serum miR-223 level in the severe group was higher than that in the common group and the control group, and the miR-24 level was lower than that in the common group and the control group (P<0.05). The serum miR-223 levels and APACHEII scores in the death group were higher than those in the survival group on the first, third, and seventh day after admission, while the miR-24 levels were lower than those in the survival group (P<0.05). The proportion of patients with mechanical ventilation in the death group was higher than that in the survival group (P<0.05). The level of serum miR-24 was negatively correlated with APACHEII score and mechanical ventilation in patients who died of severe pneumonia (P<0.05), and miR-223 was positively correlated with APACHEII score and mechanical ventilation (P<0.05). The AUC predicted by serum miR-24, miR-223, and APACHEII scores alone and jointly were 0.867, 0.839, 0.791, and 0.952, respectively. MiR-24 and miR-223 are protective and independent risk factors for mortality in severe pneumonia patients, respectively (P<0.05). MiR-24 was a protective factor affecting the death of patients with severe pneumonia, and miR-223 was an independent risk factor affecting the death of patients with severe pneumonia (P<0.05).

Conclusion: The combination of serum miR-24 and miR-223 levels on the first day after admission and APACHEII score can effectively predict prognosis.

Keywords: micro RNA-223; micro RNA-24; prognosis; severe pneumonia.

Grants and funding

There is no funding to report.