Inflammatory diseases: Function of LncRNAs in their emergence and the role of mesenchymal stem cell secretome in their treatment

Muath Suliman; Sulieman Ibraheem Shelash Al-Hawary; F Al-Dolaimy; Ahmed Hjazi; Sami G Almalki; Adnan Taan Alkhafaji; Ahmed Hussien Alawadi; Ali Alsaalamy; Sheela Bijlwan; Yasser Fakri Mustafa

doi:10.1016/j.prp.2023.154758

Inflammatory diseases: Function of LncRNAs in their emergence and the role of mesenchymal stem cell secretome in their treatment

Pathol Res Pract. 2023 Sep:249:154758. doi: 10.1016/j.prp.2023.154758. Epub 2023 Aug 9.

Affiliations

¹ Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
² Department of Business Administration, Business School, Al al-Bayt University, Mafraq, Jordan. Electronic address: dr_sliman73@aabu.edu.jo.
³ Al-Zahraa University for Women, Karbala, Iraq.
⁴ Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia. Electronic address: a.hijazi@psau.edu.sa.
⁵ Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah, Saudi Arabia.
⁶ Cardiology Department, College of Medicine, Al-Ayen University, Thi-Qar, Iraq.
⁷ College of technical engineering, the Islamic University, Najaf, Iraq; College of technical engineering, the Islamic University of Al Diwaniyah, Iraq; College of technical engineering, the Islamic University of Babylon, Iraq.
⁸ College of technical engineering, Imam Ja'afar Al-Sadiq University, Al-Muthanna, Iraq.
⁹ Uttaranchal School of Computing Sciences, Uttaranchal University, Dehradun, India.
¹⁰ Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq.

PMID: 37660657
DOI: 10.1016/j.prp.2023.154758

Abstract

One of the best treatments for inflammatory diseases such as COVID-19, respiratory diseases and brain diseases is treatment with stem cells. Here we investigate the effect of stem cell therapy in the treatment of brain diseases.Preclinical studies have shown promising results, including improved functional recovery and tissue repair in animal models of neurodegenerative diseases, strokes,and traumatic brain injuries. However,ethical implications, safety concerns, and regulatory frameworks necessitate thorough evaluation before transitioning to clinical applications. Additionally, the complex nature of the brain and its intricate cellular environment present unique obstacles that must be overcome to ensure the successful integration and functionality of genetically engineered MSCs. The careful navigation of this path will determine whether the application of genetically engineered MSCs in brain tissue regeneration ultimately lives up to the hype surrounding it.

Keywords: MSCs; Neurological disorders; Regenerative medicine; Stem cell transplantation.

Publication types

Review

MeSH terms

Animals
COVID-19*
Mesenchymal Stem Cells*
RNA, Long Noncoding*
Secretome
Stroke*

Substances

RNA, Long Noncoding