DaTSCAN® dilution with 0.9% NaCl - A stability evaluation

F Avry; O David; N Arlicot; D Darsin-Bettinger

doi:10.1016/j.apradiso.2023.111009

DaTSCAN® dilution with 0.9% NaCl - A stability evaluation

Appl Radiat Isot. 2023 Nov:201:111009. doi: 10.1016/j.apradiso.2023.111009. Epub 2023 Aug 29.

Authors

F Avry¹, O David², N Arlicot³, D Darsin-Bettinger⁴

Affiliations

¹ CHRU de Tours, Tours, France. Electronic address: francois.avry@etu.univ-tours.fr.
² CHR d'Orléans, Unité de Radiopharmacie, Orléans, France.
³ CHRU de Tours, Tours, France; UMR 1253, iBrain, Université de Tours, INSERM, Tours, France; INSERM CIC 1415, Université de Tours, INSERM, Tours, France. Electronic address: nicolas.arlicot@univ-tours.fr.
⁴ CHR d'Orléans, Unité de Radiopharmacie, Orléans, France. Electronic address: diane.darsin@chr-orleans.fr.

PMID: 37660499
DOI: 10.1016/j.apradiso.2023.111009

Abstract

¹²³I-ioflupane (DaTSCAN®, GE) is a well-known ready-to-use radiopharmaceutical employed as a visualizing tool of the brain dopamine transporter receptor distribution. According to the Summary of Product Characteristics recommendations, we evaluated the stability of the DaTSCAN® after a 0.9% sodium chloride solution dilution. No significant increase in free ¹²³I-iodide was revealed between diluted and undiluted samples over a 1-h timeframe. This stability in sodium chloride can compensate for potential dilution error and offers a suitable alternative method for syringing DaTSCAN®.

Keywords: (123)I-ioflupane; DaTSCAN®; Dilution; Stability.