Interferon signaling restrains renal cell carcinoma heterogeneity

Trends Cancer. 2023 Nov;9(11):871-873. doi: 10.1016/j.trecan.2023.08.008. Epub 2023 Aug 30.

Abstract

Type I interferon (IFN) is central to cancer surveillance as it mediates both direct and immune-mediated oncosuppressive effects. A recent study by Perelli et al. suggests that the ability of renal cancer cells to tolerate complex karyotypic alterations elicited by chromosomal instability (CIN), and ultimately acquire full metastatic potential, is also negatively regulated by IFN signaling.

Keywords: CGAS; CNV; cancer stem cells; cancer/immunity coevolution; immunoevasion.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • Carcinoma, Renal Cell* / genetics
  • Humans
  • Interferon Type I* / metabolism
  • Kidney Neoplasms* / genetics
  • Nucleotidyltransferases / metabolism
  • Signal Transduction

Substances

  • Nucleotidyltransferases
  • Interferon Type I