Haunting innate immune memories of COVID-19

Birgit Sawitzki

doi:10.1016/j.cell.2023.07.033

Haunting innate immune memories of COVID-19

Cell. 2023 Aug 31;186(18):3753-3755. doi: 10.1016/j.cell.2023.07.033.

Author

Birgit Sawitzki¹

Affiliation

¹ Translational Immunology, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. Electronic address: birgit.sawitzki@bih-charite.de.

PMID: 37657416
DOI: 10.1016/j.cell.2023.07.033

Abstract

In addition to acute hyperinflammatory responses, SARS-CoV-2 infections can have long-term effects on our immune system leading to, for example, post-acute sequelae of COVID-19 (PASC). In this issue of Cell, Cheong et al. show that severe infections via IL-6 induce persistent epigenetic signatures in hemopoietic stem cells and their myeloid progenitors associated with increased inflammatory potential.

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MeSH terms

COVID-19* / genetics
COVID-19* / immunology
COVID-19* / pathology
Epigenomics
Hematopoietic Stem Cells
Humans
Inflammation / pathology
Post-Acute COVID-19 Syndrome* / immunology
Post-Acute COVID-19 Syndrome* / pathology
SARS-CoV-2
Trained Immunity