[Diagnostic Efficacy of 68Ga-Labeled Prostate-Specific Membrane Antigen and 18F-Labeled Sodium Fluoride PET/CT in Prostate Cancer With Bone Metastasis]

An-Bo Wang; Li-Jia Feng; Ping-Ping Ni; Li-Meng He; Hong-Mei Li; Wei Zhang

doi:10.3881/j.issn.1000-503X.15336

[Diagnostic Efficacy of ⁶⁸Ga-Labeled Prostate-Specific Membrane Antigen and ¹⁸F-Labeled Sodium Fluoride PET/CT in Prostate Cancer With Bone Metastasis]

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2023 Aug;45(4):634-639. doi: 10.3881/j.issn.1000-503X.15336.

[Article in Chinese]

Authors

An-Bo Wang¹, Li-Jia Feng¹, Ping-Ping Ni¹, Li-Meng He², Hong-Mei Li³, Wei Zhang²

Affiliations

¹ Department of Nuclear Medicine,The First People's Hospital of Neijiang,Neijiang,Sichuan 641000,China.
² Department of Nuclear Medicine,Sichuan Provincial People's Hospital,Sichuan Academy of Medical Sciences,Chengdu 610072,China.
³ Department of Nuclear Medicine,Affiliated Hospital of Southwest Medical University,Luzhou,Sichuan 646000,China.

PMID: 37654144
DOI: 10.3881/j.issn.1000-503X.15336

Abstract
in English, Chinese

Objective To compare the efficiency of ⁶⁸Ga-labeled prostate-specific membrane antigen (⁶⁸Ga-PSMA-11) and ¹⁸F-labeled sodium fluoride (¹⁸F-NaF) PET/CT in the diagnosis of bone metastasis in the patients with prostate cancer.Methods The prostate cancer patients suspected of bone metastasis who underwent ⁶⁸Ga-PSMA-11 PET/CT and ¹⁸F-NaF PET/CT from January 2018 to January 2021 were included in this study.The number of lesions,maximum standardized uptake value (SUVmax),and tumor-to-background (T/B) ratio were compared between the two methods.Results ¹⁸F-NaF PET/CT detected more metastases than ⁶⁸Ga-PSMA-11 PET/CT (310 vs.264,P<0.001).The median SUVmax[23.2 (16.4,33.4) vs.4.1 (2.5,5.6)] and median T/B ratio[7.0 (4.9,9.9) vs.6.7 (3.7,9.6)] of ¹⁸F-NaF PET/CT were higher than those of ⁶⁸Ga-PSMA-11 PET/CT (all P<0.001).With the number of lesions as the indicator,the sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of ¹⁸F-NaF PET/CT were 100.0%,92.0%,92.0%,98.7%,and 100.0% respectively,and those of ⁶⁸Ga-PSMA-11 PET/CT were 85.2%,94.0%,79.2%,98.9%,and 50.5%,respectively.Conclusion ¹⁸F-NaF PET/CT is superior to ⁶⁸Ga-PSMA-11 PET/CT in the detection of bone metastases of prostate cancer.

目的对比分析⁶⁸Ga标记前列腺特异性膜抗原(⁶⁸Ga-PSMA-11)与¹⁸F标记氟化钠(¹⁸F-NaF) PET/CT对前列腺癌骨转移病灶的检出效能。方法收集2018年1月至2021年1月行⁶⁸Ga-PSMA-11 PET/CT且于1周内行¹⁸F-NaF PET/CT检查的已确诊为前列腺癌并怀疑有骨转移的患者,比较分析两种检测方法的病灶数、病灶最大标准化摄取值(SUVmax)及肿瘤/背景(T/B)比值。结果 ¹⁸F-NaF PET/CT 检出的骨转移灶(310个)显著高于⁶⁸Ga-PSMA-11 PET/CT(264个)(P<0.001);¹⁸F-NaF PET检出的 SUVmax[23.2(16.4,33.4)]及T/B值[7.0(4.9,9.9)]显著高于⁶⁸Ga-PSMA-11 PET[SUVmax:4.1(2.5,5.6);T/B:6.7(3.7,9.6)](P均<0.001)。以病灶数作为统计对象,¹⁸F-NaF PET/CT的灵敏度、特异度、准确度、阳性预测值及阴性预测值分别为100.0%、92.0%、92.0%、98.7%、100.0%;⁶⁸Ga-PSMA-11 PET/CT的灵敏度、特异度、准确度、阳性预测值及阴性预测值分别为85.2%、94.0%、79.2%、98.9%、50.5%。结论在前列腺癌骨转移灶的检测中,¹⁸F-NaF PET/CT比⁶⁸Ga-PSMA-11 PET/CT更具有优势。.

Keywords: PET/CT; prostate cancer; prostate-specific membrane antigen; sodium fluoride.

Publication types

English Abstract

Abstract in English, Chinese

Publication types

Abstract
in English, Chinese