Compared with conventional treatments, oncolytic virotherapy has the advantages of enhanced cytotoxicity, improved targeting, and minimal side effects. However, its efficacy is not as good as expected for the single drug treatment. The purpose of synergistic effect is one of the development directions of existing oncolytic virus therapy. In this paper, through a systematic review of the current preclinical and clinical trials progress of oncolytic virus combination therapy, the combined treatment strategies of oncolytic virus and immune checkpoint inhibitors, chemotherapy, targeted therapy,and cell therapy are reviewed to provide reference for further clinical application.
相较于其他肿瘤免疫疗法，溶瘤病毒具有杀伤效率高、靶向性好、不良反应小、多种杀伤肿瘤途径等优势，但其单药疗效表现不及预期。因此与传统治疗联用从而达到协同增效的目的，是现有溶瘤病毒疗法的发展方向之一。本文通过系统性回顾当前溶瘤病毒联用疗法的临床前及临床试验进展，就溶瘤病毒与免疫检查点抑制剂、化疗、靶向治疗和细胞治疗等联用治疗策略进行综述，以期为进一步的临床应用提供参考。.