Advanced Materials and Delivery Systems for Enhancement of Chimeric Antigen Receptor Cells

Small Methods. 2023 Nov;7(11):e2300880. doi: 10.1002/smtd.202300880. Epub 2023 Aug 31.

Abstract

Chimeric antigen receptor (CAR) cell therapy is a great success and breakthrough in immunotherapy. However, there are still lots of barriers to its wide use in clinical, including long time consumption, high cost, and failure against solid tumors. For these challenges, researches are deplored to explore CAR cells to more appliable products in clinical. This minireview focuses on the advanced non-viral materials for CAR-T transfection ex vivo with better performance, delivery systems combined with other therapy for enhancement of CAR-T therapy in solid tumors. In addition, the targeted delivery platform for CAR cells in vivo generation as a breakthrough technology as its low cost and convenience. In the end, the prospective direction and future of CAR cell therapy are discussed.

Keywords: CAR cells therapy; biomaterials; solid tumors; targeted delivery.

Publication types

  • Review

MeSH terms

  • Humans
  • Neoplasms* / therapy
  • Prospective Studies
  • Receptors, Antigen, T-Cell / genetics
  • Receptors, Antigen, T-Cell / therapeutic use
  • Receptors, Chimeric Antigen* / genetics
  • T-Lymphocytes

Substances

  • Receptors, Chimeric Antigen
  • Receptors, Antigen, T-Cell