Antidepressants and type 2 diabetes: highways to knowns and unknowns

Nahi Sabih Alruwaili; Hayder M Al-Kuraishy; Ali I Al-Gareeb; Ali K Albuhadily; Amany E Ragab; Ahmad Awad Alenazi; Athanasios Alexiou; Marios Papadakis; Gaber El-Saber Batiha

doi:10.1186/s13098-023-01149-z

Antidepressants and type 2 diabetes: highways to knowns and unknowns

Diabetol Metab Syndr. 2023 Aug 31;15(1):179. doi: 10.1186/s13098-023-01149-z.

Authors

Nahi Sabih Alruwaili¹, Hayder M Al-Kuraishy², Ali I Al-Gareeb², Ali K Albuhadily², Amany E Ragab³, Ahmad Awad Alenazi⁴, Athanasios Alexiou^{5

6}, Marios Papadakis⁷, Gaber El-Saber Batiha⁸

Affiliations

¹ Eradah Complex of Mental Health -Northern Border Region, Ministry of Health, Al Bahah, Saudi Arabia.
² Department of Clinical pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad, Iraq.
³ Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, Egypt. amany.ragab@pharm.tanta.edu.eg.
⁴ National guard health affairs, Riyadh, Saudi Arabia.
⁵ Department of Science and Engineering, Novel Global Community Educational Foundation, Hebersham, NSW, 2770, Australia.
⁶ AFNP Med, Wien, 1030, Austria.
⁷ Department of Surgery II, University Hospital Witten-Herdecke, Wuppertal, 42283, Germany. marios_papadakis@yahoo.gr.
⁸ Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, AlBeheira, 22511, Egypt.

Abstract

Type 2 diabetes (T2D) is a metabolic disease caused by the development of insulin resistance (IR), relative insulin deficiency, and hyperglycemia. Hyperglycemia-induced neurochemical dysregulation activates the progression of depression in T2D patients. Therefore, management of depression by antidepressant agents improves glucose homeostasis and insulin sensitivity. However, prolong use of antidepressant drugs may increase the risk for the development of T2D. However, there is strong controversy concerning the use of antidepressant drugs in T2D. Therefore, this review try to elucidate the potential effects of antidepressant drugs in T2D regarding their detrimental and beneficial effects.

Keywords: Antidepressants; Depression; Type 2 diabetes.

Publication types

Review