Circular RNA in cholangiocarcinoma: A systematic review and bibliometric analysis

Zheyu Zhou; Chaobo Chen; Bing Han; Yinyu Wang; Yang Liu; Qiaoyu Liu; Xiaoliang Xu; Yin Yin; Beicheng Sun

doi:10.1016/j.prp.2023.154755

Circular RNA in cholangiocarcinoma: A systematic review and bibliometric analysis

Pathol Res Pract. 2023 Sep:249:154755. doi: 10.1016/j.prp.2023.154755. Epub 2023 Aug 9.

Authors

Zheyu Zhou¹, Chaobo Chen², Bing Han³, Yinyu Wang⁴, Yang Liu³, Qiaoyu Liu⁵, Xiaoliang Xu⁶, Yin Yin⁷, Beicheng Sun⁸

Affiliations

¹ Department of General Surgery, Nanjing Drum Tower Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Graduate School of Peking Union Medical College, Nanjing 210008, China.
² Department of General Surgery, Xishan People's Hospital of Wuxi City, Wuxi 214105, China; Department of Hepatobiliary and Transplantation Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
³ Department of Hepatobiliary and Transplantation Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
⁴ School of Medicine, Jiangsu University, Zhenjiang 212013, China.
⁵ Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
⁶ Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. Electronic address: xuxiaoliang1990@yeah.net.
⁷ Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. Electronic address: jyinjyin@sina.com.
⁸ Department of General Surgery, Nanjing Drum Tower Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Graduate School of Peking Union Medical College, Nanjing 210008, China; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. Electronic address: sunbc@ahmu.edu.cn.

PMID: 37651837
DOI: 10.1016/j.prp.2023.154755

Abstract

Background: Cholangiocarcinoma (CCA) is a common primary liver malignancy with a poor prognosis. Many studies have demonstrated the involvement of circular RNAs (circRNAs) in tumorigenesis and progression.

Methods: Four online databases (PubMed, Web of Science, Embase, and Scopus) were searched on May 04, 2023, for original papers regarding CCA and circRNAs. Bibliometric analysis of included studies was performed on R Studio and GraphPad Prism.

Results: Thirty studies were included in the systematic review and bibliometric analysis. The systematic review showed that circRNAs were involved in CCA proliferation, invasion, metastasis, chemotherapy resistance, and other biological processes and were related to the prognosis of patients and many clinicopathological features. Exosomal circRNAs provide a new idea for the early diagnosis of CCA. The bibliometric analysis showed a significant upward trend in the number of studies on CCA and circRNAs. The 30 included papers had 201 authors and were published in 22 English journals. The first paper was published in 2018, and the second paper was the most cited (148 citations).

Conclusion: This systematic review and bibliometric analysis demonstrates that circRNAs in CCA have not been studied enough. CircRNAs play an important role in the occurrence and progression of CCA. They may become new targets for the diagnosis, treatment, and prognostic monitoring of CCA.

Keywords: Bibliometric analysis; Cholangiocarcinoma; Circular RNAs; Systematic review.

Publication types

Systematic Review
Review

MeSH terms

Bibliometrics
Bile Duct Neoplasms* / genetics
Bile Ducts, Intrahepatic
Cholangiocarcinoma* / genetics
Humans
RNA, Circular

Substances

RNA, Circular