Optimal treatment of the underlying aetiology is the most effective antimicrobial stewardship for chronic respiratory disease: a lesson learned from cystic fibrosis

Jessica Rademacher; Luise Martin; Anja Theloe; Mirjam Stahl; Marcus A Mall; Oana Joean; Jan Fuge; Gesine Hansen; Tobias Welte; Katharina Schütz; Felix C Ringshausen; Anna M Dittrich

doi:10.1183/23120541.00356-2023

Optimal treatment of the underlying aetiology is the most effective antimicrobial stewardship for chronic respiratory disease: a lesson learned from cystic fibrosis

ERJ Open Res. 2023 Aug 29;9(4):00356-2023. doi: 10.1183/23120541.00356-2023. eCollection 2023 Jul.

Authors

Jessica Rademacher^{1

2}, Luise Martin^{3

4

5}, Anja Theloe⁶, Mirjam Stahl^{3

4

5}, Marcus A Mall^{3

4

5}, Oana Joean¹, Jan Fuge^{1

2}, Gesine Hansen^{2

7}, Tobias Welte^{1

2}, Katharina Schütz⁷, Felix C Ringshausen^{1

2

8

9}, Anna M Dittrich^{2

7

9}

Affiliations

¹ Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.
² Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany.
³ Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine and Cystic Fibrosis Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
⁴ DZL, associated partner site, Berlin, Germany.
⁵ Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
⁶ Pharmacy Department, Charité - Universitätsmedizin Berlin, corporate member of Freie Universitaet Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
⁷ Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
⁸ European Reference Network on Rare and Complex Respiratory Diseases (ERN-LUNG), Frankfurt, Germany.
⁹ These authors contributed equally.

Abstract

AMS in chronic lung disease can be challenging. Causal treatment of treatable traits may be the most successful AMS strategy for patients with any chronic pulmonary disease and should be brought into focus. https://bit.ly/3ptrmV8.