The critical role of osteopontin (OPN) in fibrotic diseases

Ziyi Tang; Zijing Xia; Xiangpeng Wang; Yi Liu

doi:10.1016/j.cytogfr.2023.08.007

The critical role of osteopontin (OPN) in fibrotic diseases

Cytokine Growth Factor Rev. 2023 Dec:74:86-99. doi: 10.1016/j.cytogfr.2023.08.007. Epub 2023 Aug 23.

Authors

Ziyi Tang¹, Zijing Xia¹, Xiangpeng Wang², Yi Liu³

Affiliations

¹ Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China; Rare Diseases Center, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
² Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China; Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100000, China.
³ Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China; Rare Diseases Center, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: yiliu8999@wchscu.cn.

PMID: 37648616
DOI: 10.1016/j.cytogfr.2023.08.007

Abstract

Fibrosis is a pathological condition characterized by the excessive deposition of extracellular matrix components in tissues and organs, leading to progressive architectural remodelling and contributing to the development of various diseases. Osteopontin (OPN), a highly phosphorylated glycoprotein, has been increasingly recognized for its involvement in the progression of tissue fibrosis. This review provides a comprehensive overview of the genetic and protein structure of OPN and focuses on our current understanding of the role of OPN in the development of fibrosis in the lungs and other tissues. Additionally, special attention is given to the potential of OPN as a biomarker and a novel therapeutic target in the treatment of fibrosis.

Keywords: Fibrosis; Fibrotic disease; Myofibroblast; Osteopontin; Secreted phosphoprotein 1.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers
Fibrosis
Humans
Lung*
Osteopontin* / genetics
Osteopontin* / metabolism

Substances

Osteopontin
Biomarkers