Probing the links: Long non-coding RNAs and NF-κB signalling in atherosclerosis

Md Sadique Hussain; Obaid Afzal; Gaurav Gupta; Abdulmalik Saleh Alfawaz Altamimi; Waleed Hassan Almalki; Sami I Alzarea; Imran Kazmi; Neelima Kukreti; Saurabh Gupta; Kunjbihari Sulakhiya; Sachin Kumar Singh; Kamal Dua

doi:10.1016/j.prp.2023.154773

Probing the links: Long non-coding RNAs and NF-κB signalling in atherosclerosis

Pathol Res Pract. 2023 Sep:249:154773. doi: 10.1016/j.prp.2023.154773. Epub 2023 Aug 18.

Affiliations

¹ School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, 302017 Jaipur, Rajasthan, India.
² Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia.
³ School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura 302017, Jaipur, India; Center for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India. Electronic address: gauravpharma25@gmail.com.
⁴ Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
⁵ Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Al-Jouf, Saudi Arabia.
⁶ Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
⁷ School of Pharmacy, Graphic Era Hill University, Dehradun 248007, India.
⁸ Chameli Devi Institute of Pharmacy, Department of Pharmacology, Indore, Madhya Pradesh, India.
⁹ Neuro Pharmacology Research Laboratory (NPRL), Department of Pharmacy, Indira Gandhi National Tribal University, Amarkantak, Madhya Pradesh, India.
¹⁰ School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia.
¹¹ Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India.

PMID: 37647827
DOI: 10.1016/j.prp.2023.154773

Abstract

Atherosclerosis is a chronic inflammatory disease that involves the accumulation of lipids and immune cells in the arterial wall. NF-kB signaling is a key regulator of inflammation and is known to play a critical role in atherosclerosis. Recent studies have shown that lncRNAs can regulate NF-kB and contribute to the development and progression of atherosclerosis. Preliminary findings reveal significant alterations in the expression of specific lncRNAs in atherosclerotic lesions compared to healthy arterial tissue. Experimental evidence suggests that these dysregulated lncRNAs can influence the NF-kB pathway. By unravelling the crosstalk between lncRNAs and NF-kB signaling, this review aims to enhance our understanding of the molecular mechanisms underlying atherosclerosis. Identifying novel therapeutic targets and diagnostic markers may lead to developing interventions and management strategies for this prevalent cardiovascular disease. This review summarizes the current knowledge on the role of lncRNAs in NF-kB signaling in atherosclerosis and highlights their potential as therapeutic targets for this disease.

Keywords: Atherosclerosis; Cardiovascular diseases; IncRNAs; Inflammation; NF-kB.

Publication types

Review

MeSH terms

Atherosclerosis*
Cardiovascular Diseases*
Humans
NF-kappa B
RNA, Long Noncoding* / genetics
Signal Transduction

Substances

NF-kappa B
RNA, Long Noncoding