Quantitative evaluation of the clinical severity of hemoglobin H disease in a cohort of 591 patients using a scoring system based on regression analysis

Yumeng Liu; Yuan Zhuang; Jianhong Chen; Zeyan Zhong; Jianpei Fang; Xinyu Li; Bin Xiao; Pingping Li; Bin Lin; Zhenzhong Tao; Yidan Liang; Peng Lin; Xingmin Wang; Mengyang Song; Hualei Luo; Lang Qin; Li Huang; Jufang Tan; Hailiang Li; Tianyu Zhong; Lian Yu; Zhixiang Liu; Deguo Tang; Yongzhong Zhao; Xinhua Zhang; Yuhua Ye; Xiangmin Xu

doi:10.3324/haematol.2023.283211

Quantitative evaluation of the clinical severity of hemoglobin H disease in a cohort of 591 patients using a scoring system based on regression analysis

Haematologica. 2024 Feb 1;109(2):632-638. doi: 10.3324/haematol.2023.283211.

Authors

Yumeng Liu¹, Yuan Zhuang¹, Jianhong Chen², Zeyan Zhong², Jianpei Fang³, Xinyu Li³, Bin Xiao⁴, Pingping Li⁴, Bin Lin⁵, Zhenzhong Tao⁵, Yidan Liang¹, Peng Lin¹, Xingmin Wang¹, Mengyang Song¹, Hualei Luo¹, Lang Qin¹, Li Huang¹, Jufang Tan⁶, Hailiang Li⁷, Tianyu Zhong⁸, Lian Yu⁹, Zhixiang Liu¹⁰, Deguo Tang¹¹, Yongzhong Zhao¹², Xinhua Zhang¹³, Yuhua Ye¹⁴, Xiangmin Xu¹⁵

Affiliations

¹ Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, Guangdong.
² Department of Medical Genetics and Prenatal Diagnosis, Huizhou First Maternal and Child Health Care Hospital, Huizhou, Guangdong, 516001.
³ Department of Pediatric Hematology/Oncology, Children's Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120.
⁴ Department of Hematology, 923(rd) Hospital of the People's Liberation Army, Nanning, Guangxi 530021.
⁵ Guangzhou Huayin Healthcare Group Co., Ltd., Guangzhou 510663, Guangdong, China; Guangzhou Jiexu Gene Technology Co., Ltd., Guangzhou 510530, Guangdong.
⁶ Prenatal Diagnosis Center, Chenzhou First People's Hospital Chenzhou 423000, Hunan.
⁷ Department of Laboratory Hematology, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi.
⁸ Department of Laboratory Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi.
⁹ Department of Hematology and Rheumatology, Longyan First Hospital, Affiliated to Fujian Medical University, Longyan 364000.
¹⁰ Department of Medical Dispute, Maternal and Child Health Hospital, Heyuan517000.
¹¹ Maternal and Child Health Hospital of Yongzhou City, Yongzhou, Hunan 425000.
¹² Biologics,Gene and Cell Therapy, Frontage Laboratories, 760 Pennsylvania Dr, Exton, PA, 19341.
¹³ Department of Hematology, 923(rd) Hospital of the People's Liberation Army, Nanning, Guangxi 530021. zxh303xy@163.com.
¹⁴ Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, Guangdong. yeyuhua_genetics@163.com.
¹⁵ Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, Guangdong. xixm@smu.edu.cn.

No abstract available

MeSH terms

Humans
Regression Analysis
Retrospective Studies
Severity of Illness Index
alpha-Thalassemia*

Grants and funding

Funding: This study was supported by National Natural Science Foundation of China (Grant N. 31871265), the National Key Research and Development Program of China (grant N. 2018YFA0507800 and 2018YFA0507803) and Shanghai Municipal Science and Technology Major Project (Grant N. 2017SHZDZX01).