A comprehensive review of the effects of resveratrol on glucose metabolism: unveiling the molecular pathways and therapeutic potential in diabetes management

Mol Biol Rep. 2023 Oct;50(10):8743-8755. doi: 10.1007/s11033-023-08746-1. Epub 2023 Aug 29.

Abstract

Resveratrol, a naturally occurring polyphenolic compound predominantly found in red wine and grapes, has garnered attention for its potential role in regulating carbohydrate digestion, glucose absorption, and metabolism. This review aims to deliver a comprehensive analysis of the molecular mechanisms and therapeutic potential of resveratrol in influencing vital processes in glucose homeostasis. These processes include carbohydrate digestion, glucose absorption, glycogen storage, insulin secretion, glucose metabolism in muscle cells, and triglyceride synthesis in adipocytes.The goal of this review is to offer an in-depth understanding of the multifaceted effects of resveratrol on glucose metabolism. By doing so, it presents valuable insights into its potential applications for preventing and treating metabolic disorders. This comprehensive examination of resveratrol's impact on glucose management will contribute to the growing body of knowledge on this promising natural compound, which may benefit researchers, healthcare professionals, and individuals interested in metabolic disorder prevention and treatment.

Keywords: Glucose; Insulin; Resveratrol; Triglyceride.

Publication types

  • Review

MeSH terms

  • Adipocytes
  • Carbohydrate Metabolism*
  • Diabetes Mellitus* / drug therapy
  • Glucose
  • Humans
  • Resveratrol / pharmacology

Substances

  • Resveratrol
  • Glucose