Transmembrane Transporter Constructed from PlatinumMetal-organic Cage

Xinyu Hu; Bangkun Yue; Chen Chen; Wei Zong; Sisi Li; Haishen Yang; Yali Hou; Jian Zhang

doi:10.1002/cplu.202300426

Transmembrane Transporter Constructed from PlatinumMetal-organic Cage

Chempluschem. 2023 Sep;88(9):e202300426. doi: 10.1002/cplu.202300426.

Authors

Xinyu Hu¹, Bangkun Yue¹, Chen Chen², Wei Zong³, Sisi Li⁴, Haishen Yang⁵, Yali Hou⁶, Jian Zhang¹

Affiliations

¹ Key Laboratory of Micro-Nano Optoelectronic Devices (Wenzhou), College of Electrical and Electronic Engineering, Wenzhou University, Wenzhou, 325035, China.
² Zhejiang Marine Aquaculture Research Institute, Wenzhou, 325005, China.
³ College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar, 161006, China.
⁴ Ruian Graduate College, Wenzhou University, Wenzhou, 325035, China.
⁵ Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power College of Environmental and Chemical Engineering, Shanghai University of Electric Power, Shanghai, 200090, China.
⁶ State Key Laboratory for MechanicalBehavior of Materials School of Materials Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, China.

PMID: 37642319
DOI: 10.1002/cplu.202300426

Abstract

A perylene diimide-based metal-organic cage (MOC4c) was found to be an efficient transmembrane transporter for ions and small molecules through the internal cavity of the cage. MOC4c could selectively transport different anions, as evidenced by vesicle-based fluorescenceassays and planar lipid bilayer-based current recordings.Furthermore, MOC4c appears tofacilitate calcein transport across the lipid bilayer membrane of a livingcell, suggesting that MOC4c could be used as a biologicaltool for small molecule drugstransmembrane transportation.

Keywords: host-guest chemistry; metal-organic cages; perylene diimides; supramolecular chemistry; transmembrane transporters.

Abstract

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