[15O]H2O PET: Potential or Essential for Molecular Imaging?

Riemer H J A Slart; T Samara Martinez-Lucio; Hendrikus H Boersma; Ronald H Borra; Bart Cornelissen; Rudi A J O Dierckx; Magdalena Dobrolinska; Janine Doorduin; Paola A Erba; Andor W J M Glaudemans; Bruno Lima Giacobbo; Gert Luurtsema; Walter Noordzij; Joyce van Sluis; Charalampos Tsoumpas; Adriaan A Lammertsma

doi:10.1053/j.semnuclmed.2023.08.002

[¹⁵O]H₂O PET: Potential or Essential for Molecular Imaging?

Semin Nucl Med. 2023 Aug 26:S0001-2998(23)00070-3. doi: 10.1053/j.semnuclmed.2023.08.002. Online ahead of print.

Authors

Riemer H J A Slart¹, T Samara Martinez-Lucio², Hendrikus H Boersma², Ronald H Borra², Bart Cornelissen², Rudi A J O Dierckx², Magdalena Dobrolinska³, Janine Doorduin², Paola A Erba⁴, Andor W J M Glaudemans², Bruno Lima Giacobbo², Gert Luurtsema², Walter Noordzij², Joyce van Sluis², Charalampos Tsoumpas², Adriaan A Lammertsma²

Affiliations

¹ Department of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Biomedical Photonic Imaging, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands. Electronic address: r.h.j.a.slart@umcg.nl.
² Department of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
³ Department of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland.
⁴ Department of Medicine and Surgery, University of Milan Bicocca, and Nuclear Medicine Unit ASST Ospedale Papa Giovanni XXIII, Bergamo, Italy.

PMID: 37640631
DOI: 10.1053/j.semnuclmed.2023.08.002

Abstract

Imaging water pathways in the human body provides an excellent way of measuring accurately the blood flow directed to different organs. This makes it a powerful diagnostic tool for a wide range of diseases that are related to perfusion and oxygenation. Although water PET has a long history, its true potential has not made it into regular clinical practice. The article highlights the potential of water PET in molecular imaging and suggests its prospective role in becoming an essential tool for the 21st century precision medicine in different domains ranging from preclinical to clinical research and practice. The recent technical advances in high-sensitivity PET imaging can play a key accelerating role in empowering this technique, though there are still several challenges to overcome.

Publication types

Review