Diabetic Cardiomyopathy: 2023 Update by the International Multidisciplinary Board of Experts

Ashot Avagimyan; Federica Fogacci; Nana Pogosova; Lev Kakrurskiy; Eugenia Kogan; Olga Urazova; Zhanna Kobalava; Liudmila Mikhaleva; Rositsa Vandysheva; Gioeva Zarina; Artem Trofimenko; Grizelda Navasardyan; Lusine Mkrtchyan; Mattia Galli; Zinaida Jndoyan; Anait Aznauryan; Karmen Saahakyan; Luciano Agati; Davood Shafie; Arrigo Cicero; Giovanni Di Salvo; Nizal Sarrafzadegan

doi:10.1016/j.cpcardiol.2023.102052

Diabetic Cardiomyopathy: 2023 Update by the International Multidisciplinary Board of Experts

Curr Probl Cardiol. 2024 Jan;49(1 Pt A):102052. doi: 10.1016/j.cpcardiol.2023.102052. Epub 2023 Aug 26.

Authors

Ashot Avagimyan¹, Federica Fogacci², Nana Pogosova³, Lev Kakrurskiy⁴, Eugenia Kogan⁵, Olga Urazova⁶, Zhanna Kobalava⁷, Liudmila Mikhaleva⁴, Rositsa Vandysheva⁴, Gioeva Zarina⁴, Artem Trofimenko⁸, Grizelda Navasardyan⁹, Lusine Mkrtchyan¹⁰, Mattia Galli¹¹, Zinaida Jndoyan¹², Anait Aznauryan¹³, Karmen Saahakyan¹⁴, Luciano Agati¹⁴, Davood Shafie¹⁵, Arrigo Cicero², Giovanni Di Salvo¹⁶, Nizal Sarrafzadegan¹⁷

Affiliations

¹ Anatomical Pathology and Clinical Morphology Department, Yerevan State Medical University, Yerevan, Armenia. Electronic address: dr.ashotavagimyan@gmail.com.
² Atherosclerosis and Metabolic Disorders Unit, Alma Mater Studiorum University of Bologna, Bologna, Italy.
³ Research and Preventive Cardiology, National Medical Research Centre of Cardiology, Moscow, Russia.
⁴ A.P. Avtsyn Research Institute of Human Morphology FSBI "Petrovskiy NRCS" Moscow, Russia.
⁵ Pathology Department, Immunohistochemistry Reference Centre of Institute of Clinical Morphology and Digital Pathology, I. M. Sechenov First Moscow State Medical University, Moscow, Russia.
⁶ Pathophysiology Department, Siberian State Medical University, Tomsk, Russia.
⁷ Internal Disease and Cardiology Department, Peoples Friendship University of Russia, Moscow, Russia.
⁸ Pathophysiology Department, Kuban State Medical University, Krasnodar, Russia.
⁹ Pathophysiology Department, Yerevan State Medical University, Yerevan, Armenia.
¹⁰ Cardiology Department, Yerevan State Medical University, Yerevan, Armenia.
¹¹ Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.
¹² Internal Diseases Propaedeutic Department, Yerevan State Medical University, Yerevan, Armenia.
¹³ Histology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia.
¹⁴ Cardiology Department, Azienda Umberto I, Sapienza University, Rome, Italy.
¹⁵ Heart Failure Research Center, Isfahan Cardiovascular Research Institute, Isfahan, Iran.
¹⁶ Imperial College of London, London, Great Britain.
¹⁷ Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

PMID: 37640176
DOI: 10.1016/j.cpcardiol.2023.102052

Abstract

Diabetes mellitus (DM) is considered by many the pandemic of the 21st century and is associated with multiple organ damages. Among these, cardiovascular complications are responsible for an incredible burden of mortality and morbidity in Western Countries. The study of the pathological mechanisms responsible for the cardiovascular complications in DM patients is key for the development of new therapeutic strategies. The metabolic disorders caused by hyperglycemia, insulin resistance, and dyslipidemia, results in a cascade of pathomorphological changes favoring the atherosclerotic process and leading to myocardial remodeling. Parallel to this, oxidative stress, calcium overload, mitochondrial dysfunction, activation of protein kinase C signaling pathways, myocardial lipomatosis, and low-grade inflammation of the myocardium - are the main pathways responsible for the diabetic cardiomyopathy development. This review aims to appraise and discuss the pathogenetic mechanisms behind the diabetic cardiomyopathy development.

Publication types

Review

MeSH terms

Diabetes Mellitus*
Diabetic Cardiomyopathies* / etiology
Diabetic Cardiomyopathies* / therapy
Humans
Myocardium / metabolism
Oxidative Stress
Signal Transduction