Cinnamon modulates the pharmacodynamic & pharmacokinetic of amlodipine in hypertensive rats

Ibrahim Abdelsalam Abdelrahman; Abdul Ahad; Mohammad Raish; Yousef A Bin Jardan; Mohd Aftab Alam; Fahad I Al-Jenoobi

doi:10.1016/j.jsps.2023.101737

Cinnamon modulates the pharmacodynamic & pharmacokinetic of amlodipine in hypertensive rats

Saudi Pharm J. 2023 Sep;31(9):101737. doi: 10.1016/j.jsps.2023.101737. Epub 2023 Aug 7.

Authors

Ibrahim Abdelsalam Abdelrahman¹, Abdul Ahad¹, Mohammad Raish¹, Yousef A Bin Jardan¹, Mohd Aftab Alam¹, Fahad I Al-Jenoobi¹

Affiliation

¹ Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.

Abstract

The objective of this study was to investigate the effects of cinnamon on the pharmacodynamic (PD) & pharmacokinetic (PK) of amlodipine in hypertensive rats. The hypertensive control group of Wistar rats received L-NAME (40 mg/kg, daily, orally) only. The cinnamon group of rats was treated with cinnamon (200 mg/kg, daily, orally) along with L-NAME. Following 14 days treatment period, blood pressures of rats were monitored at designated intervals over 24 h utilizing a tail-cuff system for measuring blood pressure. To assess the oral PK; amlodipine was administered as a single oral dose of 1 mg/kg to rats and blood samples were collected at specified intervals over 24 h and analysed by UPLC-LC MS/MS. Synergistic decreased in rat's blood pressure was observed in presence of cinnamon + amlodipine. Simultaneous administration of cinnamon ameliorates the C_max and AUC_0-t of amlodipine, the C_max and AUC_0-t was 11.04 ± 1.01 ng/ml and 113.76 ± 5.62 ng h/ml for the cinnamon + amlodipine group as compared to 4.12 ± 0.49 ng/ml and 48.59 ± 4.28 ng h/ml for the amlodipine alone group. The study demonstrates that the use of cinnamon considerably decreases the blood pressure levels and enhances the PK parameters of amlodipine in hypertensive rats.

Keywords: Amlodipine; Cinnamomum zeylanicum; Cinnamon; Pharmacodynamic; Pharmacokinetic.