Early-Onset Invasive Pulmonary Aspergillosis in a Liver Transplant Patient: A Case Report

Juan P Espinosa-Leon; Theresa Feng; Andres de Lima; Brian P O'Gara

doi:10.7759/cureus.42554

Early-Onset Invasive Pulmonary Aspergillosis in a Liver Transplant Patient: A Case Report

Cureus. 2023 Jul 27;15(7):e42554. doi: 10.7759/cureus.42554. eCollection 2023 Jul.

Authors

Juan P Espinosa-Leon¹, Theresa Feng¹, Andres de Lima¹, Brian P O'Gara¹

Affiliation

¹ Anesthesiology, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.

Abstract

Invasive pulmonary aspergillosis (IPA) in liver transplant patients remains rare but exceedingly fatal. The diagnostic challenges associated with this condition are compounded by its infrequent onset within the first two weeks following transplantation. Moreover, therapeutic management is complex due to the intricate drug interactions between triazole antifungals and calcineurin inhibitor immunosuppressants. We present the case of a 63-year-old male who underwent uncomplicated liver transplantation (LT) and developed early-onset IPA. Despite maximal efforts, the patient expired. This report aims to underscore the vital importance of timely diagnosis and therapy in preventing the insidious progression of invasive disease and subsequent mortality.

Keywords: antifungal agents; clinical case report; id critical care; invasive fungal infection; invasive pulmonary aspergillosis; liver transplantation.

Publication types

Case Reports