MIR31HG, a potential lncRNA in human cancers and non-cancers

Luxi Ruan; Jing Lei; Yihang Yuan; Huizi Li; Hui Yang; Jinyan Wang; Quanan Zhang

doi:10.3389/fgene.2023.1145454

MIR31HG, a potential lncRNA in human cancers and non-cancers

Front Genet. 2023 Aug 10:14:1145454. doi: 10.3389/fgene.2023.1145454. eCollection 2023.

Authors

Luxi Ruan¹, Jing Lei¹, Yihang Yuan¹, Huizi Li¹, Hui Yang¹, Jinyan Wang², Quanan Zhang¹

Affiliations

¹ Department of Oncology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
² Department of Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Abstract

Long non-coding RNAs have recently attracted considerable attention due to their aberrant expression in human diseases. LncMIR31HG is a novel lncRNA that is abnormally expressed in multiple diseases and implicated in various stages of disease progression. A large proportion of recent studies have indicated that MIR31HG has biological functions by triggering various signalling pathways in the pathogenesis of human diseases, especially cancers. More importantly, the abnormal expression of MIR31HG makes it a potential biomarker in diagnosis and prognosis, as well as a promising target for treatments. This review aims to systematically summarize the gene polymorphism, expression profiles, biological roles, underlying mechanisms, and clinical applications of MIR31HG in human diseases.

Keywords: MIR31HG; biological function; expression; long non-coding RNA; signalling pathways.

Publication types

Review

Grants and funding

This work was funded by the Graduate Research and Innovation Projects of Jiangsu Province (SJCX22_0657).