Extracellular vesicles as a novel mediator of interkingdom communication

Jumin Huang; Xuanrun Wang; Ziming Wang; Liyan Deng; Yuwei Wang; Yuping Tang; Lianxiang Luo; Elaine Lai-Han Leung

doi:10.1016/j.cytogfr.2023.08.005

Extracellular vesicles as a novel mediator of interkingdom communication

Cytokine Growth Factor Rev. 2023 Oct:73:173-184. doi: 10.1016/j.cytogfr.2023.08.005. Epub 2023 Aug 21.

Authors

Jumin Huang¹, Xuanrun Wang¹, Ziming Wang¹, Liyan Deng², Yuwei Wang³, Yuping Tang⁴, Lianxiang Luo⁵, Elaine Lai-Han Leung⁶

Affiliations

¹ Cancer Centre, Faculty of Health Sciences, Universty of Macau, Macao Special Administrative Region of China; MOE Frontiers Science Centre for Precision Oncology, University of Macau, Macao Special Administrative Region of China.
² The Marine Biomedical Research Institute, Guangdong Medical University, China; The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, Guangdong, China.
³ Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shaanxi University of Chinese Medicine, Xi'an 712046, Shaanxi, China.
⁴ Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shaanxi University of Chinese Medicine, Xi'an 712046, Shaanxi, China. Electronic address: yupingtang@sntcm.edu.cn.
⁵ The Marine Biomedical Research Institute, Guangdong Medical University, China; The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, Guangdong, China. Electronic address: luolianxiang321@gdmu.edu.cn.
⁶ Cancer Centre, Faculty of Health Sciences, Universty of Macau, Macao Special Administrative Region of China; MOE Frontiers Science Centre for Precision Oncology, University of Macau, Macao Special Administrative Region of China; State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao Special Administrative Region of China. Electronic address: lhleung@um.edu.mo.

PMID: 37634980
DOI: 10.1016/j.cytogfr.2023.08.005

Abstract

Extracellular vesicles (EVs) are nanosized lipid bilayer-delimited particles secreted from almost all types of cells including bacteria, mammals and plants, and are presumed to be mediators of intercellular communication. Bacterial extracellular vesicles (BEVs) are nanoparticles with diverse diameters, ranging from 20 to 400 nm. BEVs are composed of soluble microbial metabolites, including nucleic acid, proteins, lipoglycans, and short-chain fatty acids (SCFAs). In addition, EVs may contain quorum sensing peptides that are endowed with the ability to protect bacteria against bacteriophages, form and maintain bacterial communities, and modulate the host immune system. BEVs are potentially promising therapeutic modalities for use in vaccine development, cancer immunotherapy regimens, and drug delivery cargos. Plant-derived EVs (PEVs), such as EVs derived from herbal medicines, can be absorbed by the gut microbiota and influence the composition and homeostasis of gut microbiota. This review highlights the roles of BEVs and PEVs in bacterial and plant physiology and discusses crosstalk among gut bacteria, host metabolism and herbal medicine. In summary, EVs represent crucial communication messengers in the gut microbiota, with potential therapeutic value in the delivery of herbal medicines.

Keywords: Extracellular vesicles; Gut microbiota; Herbal medicine; Multi-omics.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Communication
Extracellular Vesicles*
Gastrointestinal Microbiome*
Homeostasis
Humans
Mammals
Plant Extracts

Substances

Plant Extracts