Environments affect blood pressure in toddlers: The Japan Environment and Children's Study

Pediatr Res. 2024 Jan;95(1):367-376. doi: 10.1038/s41390-023-02796-8. Epub 2023 Aug 26.

Abstract

Background: The primary objective of this study was to examine risk factors for toddler's hypertension.

Methods: Subjects of this study were children and parents participating in a national birth cohort study in Japan, the Japan Environment and Children's Study. We measured the children's blood pressure (BP) at 2 and 4 years old. We obtained children's and parents' backgrounds from the questionnaire. We investigated the factors that affect BP elevation.

Results: Within 4988 participants, the mean systolic BP at 2 years old was 91.2 mmHg for boys and 90.0 mmHg for girls. The mean systolic BP at 4 years old was 93.8 mmHg for boys and 93.1 mmHg for girls. Parental smoking was associated with elevated values of BP at 2 and 4 years old. Obesity, gestational hypertension, and parental lower education were associated with elevated values of BP at 4 years old. Hypertensive group had a significantly higher obesity rate. The mother's lower education and parental smoking were involved in hypertensive groups.

Conclusion: Parental smoking had a significant effect on BP even in early toddlers. We emphasize the importance of avoiding second-hand smoking from early infancy to prevent future lifestyle-related illnesses including hypertension.

Impact: The mean systolic BP at 2 years old was 91.2 mmHg for boys and 90.0 mmHg for girls. The mean systolic BP at 4 years old was 93.8 mmHg for boys and 93.1 mmHg for girls. Obesity, parental smoking, and lower education were associated with hypertension at 4 years old. Parental smoking was associated with hypertension at 2 and 4 years old. We emphasize the importance of avoiding second-hand smoking from early infancy.

MeSH terms

  • Blood Pressure / physiology
  • Child, Preschool
  • Cohort Studies
  • Female
  • Humans
  • Hypertension* / epidemiology
  • Hypertension* / etiology
  • Japan / epidemiology
  • Male
  • Obesity
  • Tobacco Smoke Pollution* / adverse effects

Substances

  • Tobacco Smoke Pollution