Bacterial acid stress response: from cellular changes to antibiotic tolerance and phenotypic heterogeneity

Kilian Schumacher; Sophie Brameyer; Kirsten Jung

doi:10.1016/j.mib.2023.102367

Bacterial acid stress response: from cellular changes to antibiotic tolerance and phenotypic heterogeneity

Curr Opin Microbiol. 2023 Oct:75:102367. doi: 10.1016/j.mib.2023.102367. Epub 2023 Aug 24.

Authors

Kilian Schumacher¹, Sophie Brameyer¹, Kirsten Jung²

Affiliations

¹ Faculty of Biology, Microbiology, Ludwig-Maximilians-Universität München, 82152 Martinsried, Germany.
² Faculty of Biology, Microbiology, Ludwig-Maximilians-Universität München, 82152 Martinsried, Germany. Electronic address: jung@lmu.de.

PMID: 37633223
DOI: 10.1016/j.mib.2023.102367

Abstract

Most bacteria are neutralophiles but can survive fluctuations in pH in their environment. Herein, we provide an overview of the adaptation of several human, soil, and food bacteria to acid stress, mainly based on next-generation sequencing studies, highlighting common and specific strategies. We also discuss the interplay between acid stress response and antibiotic tolerance, as well as the response of individual cells.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents* / pharmacology
Bacteria* / genetics
High-Throughput Nucleotide Sequencing
Humans

Substances

Anti-Bacterial Agents