Integrated Cu-Au stereo microelectrode arrays and microfluidic channels for the electrochemical detection of glucose

Qingteng Lai; Qibin Niu; Chi Zhang; Nuno M Reis; Mengqiu Long; Fuliang Wang; Zhengchun Liu

doi:10.1016/j.foodchem.2023.137229

Integrated Cu-Au stereo microelectrode arrays and microfluidic channels for the electrochemical detection of glucose

Food Chem. 2024 Jan 30:432:137229. doi: 10.1016/j.foodchem.2023.137229. Epub 2023 Aug 21.

Authors

Qingteng Lai¹, Qibin Niu², Chi Zhang³, Nuno M Reis⁴, Mengqiu Long³, Fuliang Wang², Zhengchun Liu⁵

Affiliations

¹ Hunan Key Laboratory for Super Microstructure and Ultrafast Process, School of Physics and Electronics, Central South University, Changsha 410083, China; Department of Clinical Laboratory, Qilu Hospital of Shandong University, Jinan 250033, China.
² State Key Laboratory of High Performance Complex Manufacturing, School of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
³ Hunan Key Laboratory for Super Microstructure and Ultrafast Process, School of Physics and Electronics, Central South University, Changsha 410083, China.
⁴ Department of Chemical Engineering and Centre for Biosensors, Bioelectronics and Biodevices (C3Bio), University of Bath, Claverton Down, Bath BA27AY, UK.
⁵ Hunan Key Laboratory for Super Microstructure and Ultrafast Process, School of Physics and Electronics, Central South University, Changsha 410083, China. Electronic address: liuzhengchunseu@126.com.

PMID: 37633136
DOI: 10.1016/j.foodchem.2023.137229

Abstract

Noble and transition metal nanomaterials are widely used in glucose sensing. However, the fabrication of these sensors still suffers from complex nanomaterial synthesis process and unstable nanomaterial loading on sensing surfaces. Herein, a Cu-Au bimetallic microelectrode array was prepared via local electrochemical deposition and electrochemical reduction without the need for templates and additional nanomaterial preparation processes. Based on the COMSOL computational fluid study, the obtained microelectrode arrays combined with microfluidic channels allow the continuous and rapid detection of glucose. Large number of active sites on the surface of 3D nano-arrays contributes to excellent sensing performance for glucose, with good linear detection ranges in 10 µM to 4 × 10² µM and 4 × 10² µM to 4 × 10⁵ µM, and a low detection limit of 284 nM. The feasibility of sensor in real sample was verified by detecting glucose in beverages with good recoveries ranging from 95.50% to 104.31%.

Keywords: Electrochemical sensor; Glucose; Microelectrode arrays; Microfluidic chip; Non-enzymatic catalysis.

MeSH terms

Beverages
Glucose
Microelectrodes
Microfluidics*
Nanostructures*

Substances

Glucose