Tuning Benzylic C-H Functionalization of (Thio)xanthenes with Electrochemistry

Changji Wang; Na Yang; Chao Li; Jian He; Hongji Li

doi:10.3390/molecules28166139

Tuning Benzylic C-H Functionalization of (Thio)xanthenes with Electrochemistry

Molecules. 2023 Aug 19;28(16):6139. doi: 10.3390/molecules28166139.

Authors

Changji Wang¹, Na Yang², Chao Li², Jian He³, Hongji Li²

Affiliations

¹ School of Chemical Engineering, Anhui University of Science and Technology, 168 Taifeng Road, Huainan 232001, China.
² Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, School of Chemistry and Materials Science, Huaibei Normal University, Huaibei 235000, China.
³ Hefei New Online Technology Co., Ltd., Hefei 235000, China.

Abstract

Here, we report a tunable electrochemical benzylic C-H functionalization of (thio)xanthenes with terminal alkynes and nitriles in the absence of any catalyst or external chemical oxidant. The benzylic C-H functionalization can be well controlled by varying the electrochemical conditions, affording the specific coupling products via C-C and C-N bond formation.

Keywords: (thio)xanthenes; alkynes; benzylic C−H functionalization; electrochemistry; nitriles.

Abstract

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