Sensory gamma entrainment: Impact on amyloid protein and therapeutic mechanism

Jiaying Hu; Leyan Zheng; Ziyu Guan; Kexin Zhong; Fankai Huang; Qiankai Huang; Jing Yang; Weiyun Li; Shanshan Li

doi:10.1016/j.brainresbull.2023.110750

Sensory gamma entrainment: Impact on amyloid protein and therapeutic mechanism

Brain Res Bull. 2023 Oct 1:202:110750. doi: 10.1016/j.brainresbull.2023.110750. Epub 2023 Aug 23.

Authors

Jiaying Hu¹, Leyan Zheng¹, Ziyu Guan¹, Kexin Zhong¹, Fankai Huang¹, Qiankai Huang¹, Jing Yang², Weiyun Li², Shanshan Li³

Affiliations

¹ Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China.
² Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China; Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China.
³ Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China; Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China. Electronic address: liss0220@hzcu.edu.cn.

PMID: 37625524
DOI: 10.1016/j.brainresbull.2023.110750

Abstract

The deposition of amyloid β peptide (Aβ) is one of the main pathological features of AD. The much-talked sensory gamma entrainment may be a new treatment for Aβ load. Here we reviewed the generation and clearance pathways of Aβ, aberrant gamma oscillation in AD, and the therapeutic effect of sensory gamma entrainment on AD. In addition, we discuss these results based on stimulus parameters and possible potential mechanisms. This provides the support for sensory gamma entrainment targeting Aβ to improve AD.

Keywords: Alzheimer's disease; Amyloid beta peptide; Amyloid precursor protein; Sensory gamma entrainment.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease* / metabolism
Amyloid Precursor Protein Secretases / metabolism
Amyloid beta-Peptides* / metabolism
Amyloid beta-Protein Precursor / metabolism
Amyloidogenic Proteins / therapeutic use
Humans

Substances

Amyloid beta-Peptides
Amyloidogenic Proteins
Amyloid beta-Protein Precursor
Amyloid Precursor Protein Secretases