Temporal analysis of non-ST segment elevation-acute coronary syndrome (NSTEACS) outcomes in 'young' patients under the age of fifty: A nationwide cohort study

Nicholas Weight; Saadiq Moledina; Muhammad Rashid; Nicholas Chew; Silvia Castelletti; Gill Louise Buchanan; Sonja Salinger; Chris P Gale; Mamas A Mamas

doi:10.1016/j.ijcard.2023.131294

Temporal analysis of non-ST segment elevation-acute coronary syndrome (NSTEACS) outcomes in 'young' patients under the age of fifty: A nationwide cohort study

Int J Cardiol. 2023 Nov 15:391:131294. doi: 10.1016/j.ijcard.2023.131294. Epub 2023 Aug 23.

Authors

Nicholas Weight¹, Saadiq Moledina¹, Muhammad Rashid¹, Nicholas Chew², Silvia Castelletti³, Gill Louise Buchanan⁴, Sonja Salinger⁵, Chris P Gale⁶, Mamas A Mamas⁷

Affiliations

¹ Keele Cardiovascular Research Group, Centre for Prognosis Research, Institute for Primary Care and Health Sciences, Keele University, UK.
² Department of Cardiology, National University Heart Centre, National University Health System, Singapore, Singapore.
³ Cardiology Department, Istituto Auxologico Italiano IRCCS, San Luca Hospital, Milan, (Italy).
⁴ Cardiology Department, North Cumbria Integrated Care NHS Foundation Trust, Carlisle, UK.
⁵ Clinic for Cardiovascular Diseases, Clinical Center Niš, Faculty of Medicine, University of Niš, Niš, Serbia.
⁶ Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK; Leeds Institute of Data Analytics, University of Leeds, Leeds, UK; Department of Cardiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
⁷ Keele Cardiovascular Research Group, Centre for Prognosis Research, Institute for Primary Care and Health Sciences, Keele University, UK. Electronic address: mamasmamas1@yahoo.co.uk.

PMID: 37625485
DOI: 10.1016/j.ijcard.2023.131294

Abstract

Background: The characteristics and risk factor profile of young patients presenting with non-ST segment elevation acute coronary syndrome (NSTEACS) and how they may have changed over time is not well reported.

Methods: We identified 26,708 NSTEACS patients aged under 50 presenting to United Kingdom (UK) hospitals between 2010 and 2017 from Myocardial Ischaemia National Audit Project (MINAP). We calculated incidence of NSTEACS per 100,000 UK population, using Office of National Statistics (ONS) population estimates, prevalence of comorbidities, ethnicity, and in-hospital mortality. We formed biennial groups to enable comparison, 2010-2011, 2012-2013, 2014-2015 and 2016-2017.

Results: The incidence of NSTEACS per 100,000 population showed minimal change between 2010 and 2017 (2010: 5.4 per 100,000 and 2017; 4.9 per 100,000). Rates of smoking (2010-11; 58% and 2016-17; 53%), and family history of coronary artery disease (CAD) (2010-11; 51% and 2016-17; 44%) fell, but the proportion of patients from an ethnic minority background (2010-11; 12% and 2016-17; 20%), with diabetes mellitus (DM) (2010-11; 14%, and 2016-17; 18%) and female patients (2010-11; 22% and 2016-17; 24%) increased over the study period. Mortality from NSTEACS remained unchanged (2010-11; 1% and 2016-17; 1%).

Conclusions: The incidence of NSTEACS in patients aged under fifty has not reduced despite reduction in prevalence of risk factors such as smoking hypercholesterolaemia in those admitted to UK hospitals. Despite improved rates of early invasive coronary angiography and percutaneous coronary intervention in 'young' NSTEACS patients, in-hospital mortality remains unchanged.

Keywords: Age; Ethnicity; Invasive coronary angiography and percutaneous coronary intervention; NSTEACS.