Ginsenosides in endometrium-related diseases: Emerging roles and mechanisms

Yang-Yang Zhang; Mao-Zhi Li; Hui-Hui Shen; Ayitila Abudukeyoumu; Feng Xie; Jiang-Feng Ye; Feng-Yuan Xu; Jian-Song Sun; Ming-Qing Li

doi:10.1016/j.biopha.2023.115340

Ginsenosides in endometrium-related diseases: Emerging roles and mechanisms

Biomed Pharmacother. 2023 Oct:166:115340. doi: 10.1016/j.biopha.2023.115340. Epub 2023 Aug 23.

Authors

Yang-Yang Zhang¹, Mao-Zhi Li¹, Hui-Hui Shen², Ayitila Abudukeyoumu³, Feng Xie⁴, Jiang-Feng Ye⁵, Feng-Yuan Xu⁶, Jian-Song Sun⁷, Ming-Qing Li⁸

Affiliations

¹ Institute of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200080, People's Republic of China; Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.
² Institute of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200080, People's Republic of China.
³ Department of Gynecology, Shanghai Jiading Maternal Child Health Hospital, Shanghai 201800, People's Republic of China.
⁴ Medical Center of Diagnosis and Treatment for Cervical and Intrauterine Diseases, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, People's Republic of China.
⁵ Institute for Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore 138632, Singapore.
⁶ Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁷ School of Life Science and Health Engineering, Jiangnan University, Wuxi 214122, People's Republic of China.
⁸ Institute of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200080, People's Republic of China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200080, People's Republic of China. Electronic address: mqli@fudan.edu.cn.

PMID: 37625321
DOI: 10.1016/j.biopha.2023.115340

Abstract

Ginsenosides, agents extracted from an important herb (ginseng), are expected to provide new therapies for endometrium-related diseases. Based on the molecular types of ginsenosides, we reviewed the main pharmacological effects of ginsenosides against endometrium-related diseases (e.g., endometrial cancers, endometriosis, and endometritis). The mechanism of action of ginsenosides involves inducing apoptosis of endometrium-related cells, promoting autophagy of endometrium-related cells, regulating epithelial-mesenchymal transition (EMT) in endometrium-related cells, and activating the immune system to kill cells associated with endometrial diseases. We hope to provide a theoretical foundation for the treatment of endometrium-related diseases by ginsenosides.

Keywords: Apoptosis; Autophagy; EMT; Endometrium; Ginsenosides.

Publication types

Review

MeSH terms

Endometrial Neoplasms* / drug therapy
Endometriosis* / drug therapy
Endometrium
Female
Ginsenosides* / pharmacology
Ginsenosides* / therapeutic use
Humans
Uterine Diseases*

Substances

Ginsenosides