Aflatoxin B1 in poultry liver: Toxic mechanism

Abstract

Aflatoxin B1 (AFB1) is the most common carcinogenic toxin in livestock and poultry feed, seriously endangering poultry production and public health. Liver is the most important organ for the metabolism of exogenous and endogenous substances in the body. AFB1 produces toxicity under the biotransformation of cytochrome P450 microparticle oxidase (CYP450). Hepatocytes are the most important cells for synthesizing CYP450 enzymes, so that AFB1 has the most significant effect on the liver. AFB1 can induce liver cell damage in poultry through a variety of molecular mechanisms, and the main of damage mechanisms have been discovered so far include oxidative damage, promoting apoptosis, influencing hepatocyte gene expression, interfering with hepatocyte autophagy, pyroptosis and necroptosis. This article reviewed the molecular mechanism of AFB1 inducing liver injury in poultry, hopefully, to provid a new direction and theoretical basis for the development of a new AFB1 detoxification method.

Keywords: Aflatoxin B(1); Liver damage; Molecular mechanism; Poultry.