Deep multi-task learning for nephropathy diagnosis on immunofluorescence images

Abstract

Background and objective: As an advanced technique, immunofluorescence (IF) is one of the most widely-used medical image for nephropathy diagnosis, due to its ease of acquisition with low cost. In practice, the clinically collected IF images are commonly corrupted by blurs at different degrees, mainly because of the inaccurate focus at the acquisition stage. Although deep neural network (DNN) methods achieve the great success in nephropathy diagnosis, their performance dramatically drops over the blurred IF images. This significantly limits the potential of leveraging the advanced DNN techniques in real-world nephropathy diagnosis scenarios.

Methods: This paper first establishes two IF databases with synthetic blurs (IFVB) and real-world blurs (Real-IF) for nephropathy diagnosis, respectively, including 1,659 patients and 6,521 IF images with various degrees of blurs. According to the analysis on these two databases, we propose a deep hierarchical multi-task learning based nephropathy diagnosis (DeepMT-ND) method to bridge the gap between the low-level vision and high-level medical tasks. Specifically, DeepMT-ND simultaneously handles the main task of automatic nephropathy diagnosis, as well as the auxiliary tasks of image quality assessment (IQA) and de-blurring.

Results: Extensive experiments show the superiority of our DeepMT-ND in terms of diagnosis accuracy and generalization ability. For instance, our method performs better than nephrologists with at least 15.4% and 6.5% accuracy improvements in IFVB and Real-IF, respectively. Meanwhile, our method also achieves comparable performance in two auxiliary tasks of IQA and de-blurring on blurred IF images.

Conclusions: In this paper, we propose a new DeepMT-ND method for nephropathy diagnosis on blurred IF images. The proposed hierarchical multi-task learning framework provides the new scope to narrow the gap between the low-level vision and high-level medical tasks, and will contribute to nephropathy diagnosis in clinical scenarios. The diagnosis accuracy and generalization ability of DeepMT-ND are experimentally verified to be effective over both synthetic and real-world databases.

Keywords: De-blurring; Immunofluorescence image; Multi-task learning; Nephropathy diagnosis.