Sialylation: An alternative to designing long-acting and targeted drug delivery system

Qixiong Zhang; Shanshan Li; Rongsheng Tong; Yuxuan Zhu

doi:10.1016/j.biopha.2023.115353

Sialylation: An alternative to designing long-acting and targeted drug delivery system

Biomed Pharmacother. 2023 Oct:166:115353. doi: 10.1016/j.biopha.2023.115353. Epub 2023 Aug 21.

Authors

Qixiong Zhang¹, Shanshan Li², Rongsheng Tong³, Yuxuan Zhu⁴

Affiliations

¹ Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China. Electronic address: qixiongzhang@outlook.com.
² College of Pharmacy, Southwest Minzu University, Chengdu 610041, China.
³ Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
⁴ Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China. Electronic address: zhuyuxuan6688@163.com.

PMID: 37611437
DOI: 10.1016/j.biopha.2023.115353

Abstract

Long-acting and specific targeting are two important properties of excellent drug delivery systems. Currently, the long-acting strategies based on polyethylene glycol (PEG) are controversial, and PEGylation is incapable of simultaneously possessing targeting ability. Thus, it is crucial to identify and develop approaches to produce long-acting and targeted drug delivery systems. Sialic acid (SA) is an endogenous, negatively charged, nine-carbon monosaccharide. SA not only mediates immune escape in the body but also binds to numerous disease related targets. This suggests a potential strategy, namely "sialylation," for preparing long-acting and targeted drug delivery systems. This review focuses on the application status of SA-based long-acting and targeted agents as a reference for subsequent research.

Keywords: Long-acting; Sialic acid; Sialylation; Targeted delivery system.

Publication types

Review

MeSH terms

Carbon*
Drug Delivery Systems*
Monosaccharides
N-Acetylneuraminic Acid
Polyethylene Glycols

Substances

Carbon
Monosaccharides
N-Acetylneuraminic Acid
Polyethylene Glycols