MXene fibers-based molecularly imprinted disposable electrochemical sensor for sensitive and selective detection of hydrocortisone

Zhuo Shi; Zifeng Wang; Kaiwen Li; Yuwei Wang; Zhanhong Li; Zhigang Zhu

doi:10.1016/j.talanta.2023.125100

MXene fibers-based molecularly imprinted disposable electrochemical sensor for sensitive and selective detection of hydrocortisone

Talanta. 2024 Jan 1;266(Pt 2):125100. doi: 10.1016/j.talanta.2023.125100. Epub 2023 Aug 19.

Authors

Zhuo Shi¹, Zifeng Wang¹, Kaiwen Li¹, Yuwei Wang¹, Zhanhong Li¹, Zhigang Zhu²

Affiliations

¹ School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China.
² School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China. Electronic address: zhigang_zhu259@163.com.

PMID: 37611366
DOI: 10.1016/j.talanta.2023.125100

Abstract

A molecularly imprinted electrochemical sensor based on MXene fibers was proposed in this work. Firstly, the wet spinning technique prepared MXene fibers with a large aspect ratio, which can make the sheet-like MXene uniformly arranged, avoiding the agglomeration of MXene and improving the electrical conductivity. Afterwards, molecularly imprinted polymers (MIPs) with specific recognition sites were synthesized on the surface of MXene fibers using the electro-polymerization method. The electrochemical sensor utilized the advantages of MXene fibers and molecular imprinting techniques to gain superior selectivity and sensitivity of hydrocortisone (HC). Electrochemical tests with different concentrations of HC (0.5 nM-10.0 μM) under optimal measurement conditions exhibited excellent linearity and a limit of detection (LOD) of 0.17 nM. Furthermore, the electrochemical sensor displayed excellent selectivity, interference resistance, reproducibility, stability and outstanding application performance in serum. This work has promising applications in trace analysis in real sample.

Keywords: Electrochemical sensor; Hydrocortisone; MXene fibers; Molecularly imprinted polymer.