Common Allergens and Immune Responses Associated with Allergic Rhinitis in China

Qirong Li; Xinyi Zhang; Qiang Feng; Hengzong Zhou; Chaoyang Ma; Chao Lin; Dongxu Wang; Jianmei Yin

doi:10.2147/JAA.S420328

Common Allergens and Immune Responses Associated with Allergic Rhinitis in China

J Asthma Allergy. 2023 Aug 17:16:851-861. doi: 10.2147/JAA.S420328. eCollection 2023.

Authors

Qirong Li^#^{1

2}, Xinyi Zhang^#², Qiang Feng^#², Hengzong Zhou^#², Chaoyang Ma³, Chao Lin⁴, Dongxu Wang², Jianmei Yin¹

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, the First Hospital of Jilin University, Changchun, People's Republic of China.
² Laboratory Animal Center, College of Animal Science, Jilin University, Changchun, People's Republic of China.
³ Hepatology Hospital of Jilin Province, Changchun, People's Republic of China.
⁴ School of Grain Science and Technology, Jilin Business and Technology College, Changchun, People's Republic of China.

^# Contributed equally.

Abstract

Allergic rhinitis (AR) is a chronic allergic disease of the upper respiratory system that affects approximately 10-40% of the global population. Due to the large number of plant pollen allergens with obvious seasonal variations, AR is common in China. AR is primarily caused by the abnormal regulation of the immune system. Its pathophysiological mechanism involves a series of immune cells and immune mediators, including cytokines. The present review summarizes the common allergens in China and the complex pathophysiological mechanism of AR. Additionally, host allergen contact, signal transduction, immune cell activation, cytokine release, and a series of inflammatory reactions are described according to their sequence of occurrence.

Keywords: allergic rhinitis; histamine; host immune response; immunoglobulin E; inflammation.

Publication types

Review

Grants and funding

This work was supported by the Jilin Province University Key Laboratory Scientific Research Program under Grant [2019] No. 004, the Jilin Education Department Program under Grant JJKH20230259KJ, the Jilin Province Development and Reform Commission Program under Grant 2023C028-6, and the Jilin Scientific and Technological Development Program under Grant 20210101010JC and 20220505033ZP.