Identification of PSMB4 and PSMD4 as novel target genes correlated with 1q21 amplification in patients with smoldering myeloma and multiple myeloma

Haematologica. 2024 Feb 1;109(2):627-631. doi: 10.3324/haematol.2023.283200.

Authors

Jessica Burroughs Garcia¹, Paola Storti², Nicolas Thomas Iannozzi², Valentina Marchica², Luca Agnelli³, Denise Toscani², Valentina Franceschi⁴, Giannalisa Todaro¹, Gabriella Sammarelli¹, Laura Notarfranchi², Matteo Scita¹, Benedetta Dalla Palma¹, Vincenzo Raimondi², Oxana Lungu², Giancarlo Pruneri³, Gaetano Donofrio⁴, Nicola Giuliani⁵

Affiliations

¹ Hematology and BMT Unit, "Azienda Ospedaliero-Universitaria di Parma", Parma.
² Department of Medicine and Surgery, University of Parma, Parma.
³ Istituto Nazionale dei Tumori Foundation, Milan.
⁴ Department of Medical-Veterinary Science, University of Parma, Parma.
⁵ Hematology and BMT Unit, "Azienda Ospedaliero-Universitaria di Parma", Parma, Italy; Department of Medicine and Surgery, University of Parma, Parma. nicola.giuliani@unipr.it.

No abstract available

MeSH terms

Chromosome Aberrations
Gene Amplification
Humans
Multiple Myeloma* / diagnosis
Multiple Myeloma* / genetics
Proteasome Endopeptidase Complex / metabolism
RNA-Binding Proteins / genetics
Smoldering Multiple Myeloma*

Substances

PSMD4 protein, human
RNA-Binding Proteins
PSMB4 protein, human
Proteasome Endopeptidase Complex

Grants and funding

Funding: This work was supported by a grant from Ricerca Finalizzata del Ministero della Salute Italiana (PE-2016-02361261).