Application of metabolomics in irritable bowel syndrome in recent 5 years

Ying Gao; Peilun Ding; Junmin Wang; Caiyun Zhang; Guang Ji; Tao Wu

doi:10.1016/j.intimp.2023.110776

Application of metabolomics in irritable bowel syndrome in recent 5 years

Int Immunopharmacol. 2023 Nov;124(Pt A):110776. doi: 10.1016/j.intimp.2023.110776. Epub 2023 Aug 19.

Authors

Ying Gao¹, Peilun Ding², Junmin Wang², Caiyun Zhang², Guang Ji³, Tao Wu⁴

Affiliations

¹ Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
² Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
³ Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. Electronic address: jg@shutcm.edu.cn.
⁴ Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: wutao001827@163.com.

PMID: 37603947
DOI: 10.1016/j.intimp.2023.110776

Abstract

Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders worldwide, characterized by chronic abdominal pain or discomfort and altered bowel habits. To date, the exact pathogenesis of IBS remains elusive, but is clearly multifactorial, including environmental and host factors. However, the management of patients with IBS is challenging and the current diagnostic and therapeutic modalities have unsatisfactory outcomes. Therefore, it is important to develop more effective methods to diagnose IBS early. Metabolomics studies the metabolites most closely related to patient characteristics, which can provide useful clinical biomarkers that can be applied to IBS and may open up new diagnostic approaches. Traditional Chinese medicine (TCM) can play a role in improving symptoms and protecting target organs, but its mechanism needs to be studied in depth. In this review, based on PubMed/MEDLINE and other databases, we searched metabolomics studies related to IBS in the past 5 years, including those related to clinical studies and animal studies, as well as literatures on TCM interventions in IBS, to provide an updated overview of the application of metabolomics to the diagnosis and treatment of IBS and the improvement of IBS by TCM.

Keywords: Irritable bowel syndrome; Metabolomics; TCM.

Publication types

Review