To evaluate the impact of strabismus surgery on sensory eye balance in patients with intermittent exotropia (IXT). In total, 112 IXT patients with ocular alignment at the first strabismus surgery and 34 controls were enrolled from January 2015 to December 2016 in this retrospective study. The effective contrast ratio (ECR) of non-dominant eyes was measured by binocular phase combination paradigm before and 3 months after surgery, and the degree of sensory eye balance was quantitatively evaluated and compared between IXT patients and controls. The preoperative and postoperative mean ECRs of IXT patients were 0.492 ± 0.182 and 0.684 ± 0.198, respectively, which were significantly lower than those of the control group (0.896 ± 0.214, both P < .001). In addition, the postoperative ECR was significantly higher than the preoperative ECR (P < .001). The ECR change was not correlated with age orstrabismus degree measured with a6 m accommodative target (both P > .05), while significant negative correlation was observed between the ECR change and strabismus degree measured with a 33 cm accommodative target (P = .002). Strabismus surgery can significantly reduce the degree of sensory eye imbalance in patients with IXT, while further treatment aimed at rebalancing the ocular dominance might be necessary for more efficient binocular visual processing in the long-term.
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