NLR immune receptors: structure and function in plant disease resistance

Alexander Förderer; Jiorgos Kourelis

doi:10.1042/BST20221087

NLR immune receptors: structure and function in plant disease resistance

Biochem Soc Trans. 2023 Aug 31;51(4):1473-1483. doi: 10.1042/BST20221087.

Authors

Alexander Förderer¹, Jiorgos Kourelis²

Affiliations

¹ Max-Planck-Institute of Molecular Plant Physiology, 14476 Potsdam, Germany.
² The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, NR4 7UH Norwich, U.K.

Abstract

Nucleotide-binding and leucine-rich repeat receptors (NLRs) are a diverse family of intracellular immune receptors that play crucial roles in recognizing and responding to pathogen invasion in plants. This review discusses the overall model of NLR activation and provides an in-depth analysis of the different NLR domains, including N-terminal executioner domains, the nucleotide-binding oligomerization domain (NOD) module, and the leucine-rich repeat (LRR) domain. Understanding the structure-function relationship of these domains is essential for developing effective strategies to improve plant disease resistance and agricultural productivity.

Keywords: NLR; phytopathology; plant biology; plant signal transduction.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Agriculture*
Disease Resistance*
Humans
Leucine
Nucleotides
Protein Domains
Receptors, Immunologic

Substances

Leucine
Receptors, Immunologic
Nucleotides