Emerging role of exosome-derived non-coding RNAs in tumor-associated angiogenesis of tumor microenvironment

Sai-Li Duan; Wei-Jie Fu; Ying-Ke Jiang; Lu-Shan Peng; Diabate Ousmane; Zhe-Jia Zhang; Jun-Pu Wang

doi:10.3389/fmolb.2023.1220193

Emerging role of exosome-derived non-coding RNAs in tumor-associated angiogenesis of tumor microenvironment

Front Mol Biosci. 2023 Aug 4:10:1220193. doi: 10.3389/fmolb.2023.1220193. eCollection 2023.

Authors

Sai-Li Duan^{1

2}, Wei-Jie Fu², Ying-Ke Jiang¹, Lu-Shan Peng³, Diabate Ousmane^{2

3}, Zhe-Jia Zhang^{1

2}, Jun-Pu Wang^{2

3

4

5}

Affiliations

¹ Department of General Surgery, Xiangya Hospital Central South University, Changsha, China.
² Xiangya School of Medicine, Central South University, Changsha, China.
³ Department of Pathology, Xiang-ya Hospital, Central South University, Changsha, China.
⁴ Key Laboratory of Hunan Province in Neurodegenerative Disorders, Xiangya Hospital, Central South University, Changsha, China.
⁵ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.

Abstract

The tumor microenvironment (TME) is an intricate ecosystem that is actively involved in various stages of cancer occurrence and development. Some characteristics of tumor biological behavior, such as proliferation, migration, invasion, inhibition of apoptosis, immune escape, angiogenesis, and metabolic reprogramming, are affected by TME. Studies have shown that non-coding RNAs, especially long-chain non-coding RNAs and microRNAs in cancer-derived exosomes, facilitate intercellular communication as a mechanism for regulating angiogenesis. They stimulate tumor growth, as well as angiogenesis, metastasis, and reprogramming of the TME. Exploring the relationship between exogenous non-coding RNAs and tumor-associated endothelial cells, as well as their role in angiogenesis, clinicians will gain new insights into treatment as a result.

Keywords: cancer; endothelial cells; exosomes; exosomes-derived non-coding RNAs; lncRNA; miRNA; tumor microenvironment; tumorassociated angiogenesis.

Publication types

Review

Grants and funding

This work was partially supported by the National Natural Science Foundation of China (project NO. 81602167), the Hunan Provincial Natural Science Foundation of China (project NO. 2017JJ3494 and 2021JJ31100), and the Science and Technology Program Foundation of Changsha City (project NO. kq2004085).