Levels of inflammatory markers are differentially expressed in sickle cell anemia and sickle cell trait

Ingrid Cristiane Pereira Gomes; Lucas Sousa Magalhães; Lays Gisele Santos Bomfim; Priscila Lima Dos Santos; Roberto Jerônimo Dos Santos Silva; Maria Carollyne Passos Cruz; Lindemberg Costa de Albuquerque; Victoria Haydée Deusdedith Neves; Paula Gabriella Pereira Rosa de Oliveira; Alessandro Freire Carvalho; Lucas Oliveira Silva; Matheus Todt Aragão; Tatiana Rodrigues Moura; Rosana Cipolotti

doi:10.1002/jha2.712

Levels of inflammatory markers are differentially expressed in sickle cell anemia and sickle cell trait

EJHaem. 2023 May 26;4(3):705-709. doi: 10.1002/jha2.712. eCollection 2023 Aug.

Authors

Ingrid Cristiane Pereira Gomes^{1

2

3}, Lucas Sousa Magalhães^{1

4

5}, Lays Gisele Santos Bomfim¹, Priscila Lima Dos Santos^{1

4

6}, Roberto Jerônimo Dos Santos Silva⁷, Maria Carollyne Passos Cruz^{1

8}, Lindemberg Costa de Albuquerque³, Victoria Haydée Deusdedith Neves³, Paula Gabriella Pereira Rosa de Oliveira⁸, Alessandro Freire Carvalho⁹, Lucas Oliveira Silva², Matheus Todt Aragão¹, Tatiana Rodrigues Moura^{1

10

5}, Rosana Cipolotti^{1

2}

Affiliations

¹ Health Sciences Graduate Program Federal University of Sergipe Aracaju Sergipe Brazil.
² Department of Medicine Federal University of Sergipe Aracaju Sergipe Brazil.
³ Department of Medicine Tiradentes University Aracaju Sergipe Brazil.
⁴ Laboratory of Molecular Biology and Immunology Federal University of Sergipe Aracaju Sergipe Brazil.
⁵ Sector of Parasitology and Pathology Biological and Health Sciences Institute Federal University of Alagoas Maceió Alagoas Brazil.
⁶ Department of Health Education Federal University of Sergipe Lagarto Sergipe Brazil.
⁷ Department of Physical Education Federal University of Sergipe, São Cristóvão, Sergipe, Brazil São Cristóvão Sergipe Brazil.
⁸ Department of Nutrition Federal University of Sergipe Lagarto Sergipe Brazil.
⁹ Department of Nutrition Tiradentes University Aracaju Sergipe Brazil.
¹⁰ Department of Morphology Federal University of Sergipe São Cristóvão Sergipe Brazil.

Abstract

Although sickle cell anemia (SCA) is related to inflammation, the profile of inflammatory markers in sickle cell trait (SCT) is poorly studied. This is a cross-sectional study of inflammatory biomarkers carried out involving adults with SCA in steady state, SCT and controls. The SCA group had higher levels of lactato dehydrogenase, IL-1β, IL-6, IL-10, and tumor necrosis factor alpha than the others, while the SCT group had similar levels to control group. In addition, SCA group had lower IL-8/IL-10 and soluble triggering receptor expressed on myeloid cells-1/IL-10 ratios. These findings indicate that individuals with SCT do not have a chronic inflammatory profile and reinforce that cytokines are involved in the maintenance of the inflammatory state in SCA.

Keywords: adults; cytokines; inflammation; sickle cell anemia; sickle cell trait.