Regulation of insulin secretion by the post-translational modifications

Chunhua Yang; Mengna Wei; Yanpu Zhao; Zhanyi Yang; Mengyao Song; Jia Mi; Xiaoyong Yang; Geng Tian

doi:10.3389/fcell.2023.1217189

Regulation of insulin secretion by the post-translational modifications

Front Cell Dev Biol. 2023 Aug 4:11:1217189. doi: 10.3389/fcell.2023.1217189. eCollection 2023.

Authors

Chunhua Yang¹, Mengna Wei¹, Yanpu Zhao¹, Zhanyi Yang¹, Mengyao Song¹, Jia Mi¹, Xiaoyong Yang², Geng Tian¹

Affiliations

¹ Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, Shandong, China.
² Yale Center for Molecular and Systems Metabolism, Department of Comparative Medicine, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, United States.

Abstract

Post-translational modification (PTM) has a significant impact on cellular signaling and function regulation. In pancreatic β cells, PTMs are involved in insulin secretion, cell development, and viability. The dysregulation of PTM in β cells is clinically associated with the development of diabetes mellitus. Here, we summarized current findings on major PTMs occurring in β cells and their roles in insulin secretion. Our work provides comprehensive insight into understanding the mechanisms of insulin secretion and potential therapeutic targets for diabetes from the perspective of protein PTMs.

Keywords: O-GlcNAcylation; PTMs; acetylation; insulin secretion; palmitoylation; phosphorylation; sumoylation; ubiquitination.

Publication types

Review

Grants and funding

This research was funded by Taishan Scholars Construction Engineering, National Natural Science Foundation of China (32170989), Major Basic Research Project of Shandong Provincial Natural Science Foundation (ZR2019ZD27), Natural Science Foundation of Shandong Province (ZR2021MH141) and Shandong Province Higher Educational Youth Innovation Science and Technology Program (2019KJE013).