Osteopontin levels correlate with severity of diabetic cardiomyopathy in early stage of diabetes

Alessandro Scuricini; Francesco Andreozzi; Cosimo Sgura; Stefano Ministrini; Maria Bertolotto; Davide Ramoni; Luca Liberale; Giovanni G Camici; Gaia C Mannino; Elena Succurro; Giuseppe Armentaro; Teresa V Fiorentino; Velia Cassano; Sofia Miceli; Maria Perticone; Mariangela Rubino; Giorgio Sesti; Fabrizio Montecucco; Angela Sciacqua; Federico Carbone

doi:10.1016/j.diabres.2023.110885

Osteopontin levels correlate with severity of diabetic cardiomyopathy in early stage of diabetes

Diabetes Res Clin Pract. 2023 Sep:203:110885. doi: 10.1016/j.diabres.2023.110885. Epub 2023 Aug 19.

Authors

Alessandro Scuricini¹, Francesco Andreozzi², Cosimo Sgura¹, Stefano Ministrini³, Maria Bertolotto¹, Davide Ramoni¹, Luca Liberale⁴, Giovanni G Camici³, Gaia C Mannino², Elena Succurro², Giuseppe Armentaro², Teresa V Fiorentino², Velia Cassano², Sofia Miceli², Maria Perticone², Mariangela Rubino², Giorgio Sesti⁵, Fabrizio Montecucco⁴, Angela Sciacqua², Federico Carbone⁶

Affiliations

¹ First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy.
² Department of Medical and Surgical Sciences, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.
³ Center for Molecular Cardiology, University of Zürich, 12 Wagistrasse, 8952 Schlieren, Switzerland.
⁴ First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa - Italian Cardiovascular Network, 10 Largo Rosanna Benzi Genoa, Italy.
⁵ Department of Clinical and Molecular Medicine, University of Rome-Sapienza, Rome, Italy.
⁶ First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa - Italian Cardiovascular Network, 10 Largo Rosanna Benzi Genoa, Italy. Electronic address: federico.carbone@unige.it.

PMID: 37598938
DOI: 10.1016/j.diabres.2023.110885

Abstract

Diabetic cardiomyopathy (DbCM) is characterized by restrictive pattern and consistent risk of overt heart failure. We here focused osteopontin (OPN), which was tested independently associated with left ventricular diastolic dysfunction (LVDD). Overall, OPN increased with DbCM severity according with the presence of left atrial dilatation, LV hypertrophy and LVDD.

Keywords: Diabetic cardiomyopathy; Echocardiography; Osteopontin; Type 2 diabetes mellitus.

MeSH terms

Diabetes Mellitus*
Diabetic Cardiomyopathies*
Diastole
Heart Failure* / complications
Humans
Osteopontin
Ventricular Dysfunction, Left* / etiology

Substances

Osteopontin