Platelet-membrane camouflaged cerium nanoparticle-embedded gelatin methacryloyl hydrogel for accelerated diabetic wound healing

Hang Dong; Jian Li; Xueyuan Huang; Haiting Liu; Rong Gui

doi:10.1016/j.ijbiomac.2023.126393

Platelet-membrane camouflaged cerium nanoparticle-embedded gelatin methacryloyl hydrogel for accelerated diabetic wound healing

Int J Biol Macromol. 2023 Aug 16:251:126393. doi: 10.1016/j.ijbiomac.2023.126393. Online ahead of print.

Authors

Hang Dong¹, Jian Li¹, Xueyuan Huang¹, Haiting Liu¹, Rong Gui²

Affiliations

¹ Department of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Department of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: 600957@csu.edu.cn.

PMID: 37595703
DOI: 10.1016/j.ijbiomac.2023.126393

Abstract

Impaired angiogenesis and excessive inflammation are major factors contributing to delayed wound healing in diabetic patients. This study presents the development of a novel multifunctional hydrogel, Pltm@CNPs/Gel, which incorporates platelet membrane camouflaged cerium nanoparticles into a gelatin methacryloyl matrix. The Pltm@CNPs/Gel nanocomposite hydrogel was characterized and tested for its effects on platelet activation, coagulation, cell viability, anti-oxidation, and anti-inflammation in vitro. Moreover, we evaluated the wound healing potential of the hydrogel in a diabetic rat model. Our findings demonstrate that the Pltm@CNPs/Gel hydrogel possesses anti-oxidative and anti-inflammatory properties. Furthermore, it accelerates diabetic wound healing by promoting neovascularization, cell proliferation, and collagen fiber organization. This study highlights the potential of the Pltm@CNPs/Gel hydrogel as a therapeutic option for diabetic wound healing and its promising applications as a diabetic wound dressing candidate.

Keywords: Angiogenesis; Diabetes; GelMA hydrogel; Wound healing.