Bioactive diterpenoids isolated from the twigs and leaves of Casearia velutina

Yan Li; Jian-Mei Li; Yao-Jun Xu; Xue-Dan Zu; Han He; Yan Sun; Rui-Han Zhang; Xing-Jie Zhang; Xiao-Li Li; Wei-Lie Xiao

doi:10.1016/j.fitote.2023.105654

Bioactive diterpenoids isolated from the twigs and leaves of Casearia velutina

Fitoterapia. 2023 Dec:171:105654. doi: 10.1016/j.fitote.2023.105654. Epub 2023 Aug 16.

Authors

Yan Li¹, Jian-Mei Li¹, Yao-Jun Xu¹, Xue-Dan Zu¹, Han He¹, Yan Sun¹, Rui-Han Zhang¹, Xing-Jie Zhang², Xiao-Li Li³, Wei-Lie Xiao⁴

Affiliations

¹ Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming 650500, People's Republic of China.
² Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming 650500, People's Republic of China. Electronic address: zhangxj@ynu.edu.cn.
³ Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming 650500, People's Republic of China. Electronic address: lixiaoli@ynu.edu.cn.
⁴ Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming 650500, People's Republic of China. Electronic address: xiaoweilie@ynu.edu.cn.

PMID: 37595644
DOI: 10.1016/j.fitote.2023.105654

Abstract

Nine previously undescribed clerodane-type diterpenoids (1-9), named caseabalanspenes A-I, along with six know compounds (10-15), were isolated from the twigs and leaves of Casearia velutina. Spectroscopic data (1D and 2D NMR) analysis permitted the definition of their structures and then determination of the molecular formula of the compound by high resolution mass spectrometry (HR-ESI-MS). It is worth noting that compound 7 contains N- heterocycle. Compounds 1-8 were tested the anti-inflammasome activity, and compound 3 exhibited potent activity and decreased LDH level in a dose-dependent manner, with IC₅₀ values of 2.90 μM.

Keywords: Anti-inflammasome activity; Casearia velutina; Clerodane diterpenoids.

MeSH terms

Antineoplastic Agents, Phytogenic*
Casearia* / chemistry
Diterpenes, Clerodane*
Drug Screening Assays, Antitumor
Molecular Structure
Plant Leaves / chemistry

Substances

Antineoplastic Agents, Phytogenic
Diterpenes, Clerodane