Toll-like receptor 4: A potential therapeutic target for multiple human diseases

Jinrui Wei; Yan Zhang; Haopeng Li; Fuquan Wang; Shanglong Yao

doi:10.1016/j.biopha.2023.115338

Toll-like receptor 4: A potential therapeutic target for multiple human diseases

Biomed Pharmacother. 2023 Oct:166:115338. doi: 10.1016/j.biopha.2023.115338. Epub 2023 Aug 16.

Authors

Jinrui Wei¹, Yan Zhang¹, Haopeng Li¹, Fuquan Wang¹, Shanglong Yao²

Affiliations

¹ Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, China.
² Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, China. Electronic address: yaoshanglong@hust.edu.cn.

PMID: 37595428
DOI: 10.1016/j.biopha.2023.115338

Abstract

The immune response plays a pivotal role in the pathogenesis of diseases. Toll-like receptor 4 (TLR4), as an intrinsic immune receptor, exhibits widespread in vivo expression and its dysregulation significantly contributes to the onset of various diseases, encompassing cardiovascular disorders, neoplastic conditions, and inflammatory ailments. This comprehensive review centers on elucidating the architectural and distributive characteristics of TLR4, its conventional signaling pathways, and its mode of action in diverse disease contexts. Ultimately, this review aims to propose novel avenues and therapeutic targets for clinical intervention.

Keywords: Cardiovascular; Immune response; Inflammatory; Neoplastic; Toll-like receptor 4.

Publication types

Review

MeSH terms

Cardiovascular Diseases*
Humans
Toll-Like Receptor 4*

Substances

Toll-Like Receptor 4