LiBF4-Promoted Aromatic Fluorodetriazenation under Mild Conditions

J Org Chem. 2023 Sep 1;88(17):12826-12834. doi: 10.1021/acs.joc.3c01239. Epub 2023 Aug 18.

Abstract

An efficient and mild fluorination method through LiBF4-promoted aromatic fluorodetriazenation of 3,3-dimethyl-1-aryltriazenes is developed. The reaction proceeds smoothly and tends to complete within 2 h in the absence of a protic acid or strong Lewis acid. This method tolerates a wide range of functional groups and affords the aryl fluoride products in moderate to excellent yields.