The effect of bladder function on the efficacy of transurethral prostatectomy in patients with benign prostatic hyperplasia: a retrospective, single-center study

Jin Li; Xian-Yan-Ling Yi; Ze-Yu Chen; Bo Chen; Yin Huang; Da-Zhou Liao; Pu-Ze Wang; De-Hong Cao; Jian-Zhong Ai; Liang-Ren Liu

doi:10.4103/aja202327

The effect of bladder function on the efficacy of transurethral prostatectomy in patients with benign prostatic hyperplasia: a retrospective, single-center study

Asian J Androl. 2023 Aug 11;26(1):112-118. doi: 10.4103/aja202327. Online ahead of print.

Authors

Jin Li^{1

2}, Xian-Yan-Ling Yi^{1

2}, Ze-Yu Chen^{1

2}, Bo Chen^{1

2}, Yin Huang^{1

2}, Da-Zhou Liao¹, Pu-Ze Wang^{1

2}, De-Hong Cao², Jian-Zhong Ai², Liang-Ren Liu²

Affiliations

¹ West China School of Medicine, Sichuan University, Chengdu 610041, China.
² Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.

Abstract

We investigated the impact and predictive value of bladder function in patients with benign prostatic hyperplasia (BPH) on the efficacy of transurethral prostatectomy. Symptomatic, imaging, and urodynamic data of patients who underwent transurethral prostatectomy at West China Hospital of Sichuan University (Chengdu, China) from July 2019 to December 2021 were collected. Follow-up data included the quality of life (QoL), International Prostate Symptom Score (IPSS), and IPSS storage and voiding (IPSS-s and IPSS-v). Moreover, urinary creatinine (Cr), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and prostaglandin estradiol (PGE2) were measured in 30 patients with BPH and 30 healthy participants. Perioperative indicators were determined by subgroup analyses and receiver operating characteristic (ROC) curve analysis. Among the 313 patients with BPH included, patients with severe micturition problems had more improvements but higher micturition grades postoperatively than those with moderate symptoms. Similarly, good bladder sensation, compliance, and detrusor contractility (DC) were predictors of low postoperative IPSS and QoL. The urinary concentrations of BDNF/Cr, NGF/Cr, and PGE2/Cr in patients were significantly higher than those in healthy participants (all P < 0.001). After evaluation, only DC was significantly related to both urinary indicators and postoperative recovery of patients. Patients with good DC, as predicted by urinary indicators, had lower IPSS and IPSS-v than those with reduced DC at the 1st month postoperatively (both P < 0.05). In summary, patients with impaired bladder function had poor recovery. The combined levels of urinary BDNF/Cr, NGF/Cr, and PGE2/Cr in patients with BPH may be valid predictors of preoperative bladder function and postoperative recovery.