Nanotechnology-Based Drug Delivery of Topical Antifungal Agents

Sumita Singh; Vaishali M Patil; Sarvesh Kumar Paliwal; Neeraj Masand

doi:10.2174/2211738511666230818125031

Nanotechnology-Based Drug Delivery of Topical Antifungal Agents

Pharm Nanotechnol. 2023 Aug 18. doi: 10.2174/2211738511666230818125031. Online ahead of print.

Authors

Sumita Singh^{1

2}, Vaishali M Patil³, Sarvesh Kumar Paliwal¹, Neeraj Masand³

Affiliations

¹ Department of Pharmacy, Banasthali Vidyapith, Tonk, Rajasthan, India.
² Swami Vivekanand Subharati University, Meerut, Uttar Pradesh, India.
³ Department of Pharmaceutical Chemistry, KIET School of Pharmacy, KIET Group of Institutions, Delhi-NCR, Ghaziabad, Uttar Pradesh, India.

PMID: 37594096
DOI: 10.2174/2211738511666230818125031

Abstract

Among the various prominent fungal infections, superficial ones are widespread. A large number of antifungal agents and their formulations for topical use are commercially available. They have some pharmacokinetic limitations which cannot be retracted by conventional delivery systems. While nanoformulations composed of lipidic and polymeric nanoparticles have the potential to overcome the limitations of conventional systems. The broad spectrum category of antifungals i.e. azoles (ketoconazole, voriconazole, econazole, miconazole, etc.) nanoparticles have been designed, prepared and their pharmacokinetic and pharmacodynamic profile was established. This review briefly elaborates on the types of nano-based topical drug delivery systems and portrays their advantages for researchers in the related field to benefit the available antifungal therapeutics.

Keywords: Antifungal agents; Azoles; Drug delivery systems; Nanotechnology; Topical agents.