First clinical experience of a ring-configured cadmium zinc telluride camera: A comparative study versus conventional gamma camera systems

Abstract

Background: A novel semiconductor cadmium zinc telluride (CZT) gamma camera system using a block sequential regularized expectation maximization (BSREM) reconstruction algorithm is now clinically available. Here we investigate how a multi-purpose ring-configurated CZT system can be safely applied in clinics and describe the initial optimization process.

Method: Seventy-six patients (bone-, cardiac- and lung scan) were scanned on a conventional gamma camera (planar and/or single-photon emission computed tomography [SPECT]/SPECT-CT) used in clinical routine and on the ring-configurated CZT camera Starguide (GE Healthcare). These data were used to validate and optimize the Starguide system for routine clinical use.

Results: Comparable image quality for the Starguide system, to that of the conventional gamma camera, was achieved for bone scan (4 min/bed position [BP] using a relative difference prior [RDP] with gamma 2 and beta 0.4, along with 10 iterations and 10 subsets), cardiac scan (8 min [stress] and 3 min 20 s [rest] using median root prior [MRP] with beta 0.07 non attenuation corrected and 0.008 attenuation corrected and 50 interations and 10 subsets for both stress and rest) and lung scan (10 min [vent] and 5 min [perf] using RDP with gamma 0.5 and beta 0.03 [vent] and 0.02 [perf] and 20 interations and 10 subsets for both vent and perf).

Conclusions: It was possible to transition from a conventional gamma camera to the Starguide system as part of the clinical routine, with acceptable image quality. Images from the Starguide system were deemed to be at least as good as those from a conventional gamma camera.

Keywords: SPECT; clinical experience; molecular imaging; whole-body CZT.