Four New Stilbene Derivatives Isolated from Gnetum latifolium var. funiculare Markgr. and Their Inhibition of NO Production in LPS-activated RAW264.7 Cells

Trinh Thi Thuy; Nguyen Thi Thu Hoa; Nguyen Thi Thuy Linh; Ba Thi Cham; Nguyen Thi Hoang Anh; Nguyen Tuan Hiep; Sabrina Adorisio; Domenico V Delfino; Ngo Anh Bang; Bui Huu Tai; Phan Van Kiem

doi:10.1002/cbdv.202301166

Four New Stilbene Derivatives Isolated from Gnetum latifolium var. funiculare Markgr. and Their Inhibition of NO Production in LPS-activated RAW264.7 Cells

Chem Biodivers. 2023 Oct;20(10):e202301166. doi: 10.1002/cbdv.202301166. Epub 2023 Oct 2.

Authors

Trinh Thi Thuy^{1

2}, Nguyen Thi Thu Hoa^{1

3}, Nguyen Thi Thuy Linh^{1

2}, Ba Thi Cham^{1

2}, Nguyen Thi Hoang Anh^{1

2}, Nguyen Tuan Hiep⁴, Sabrina Adorisio⁵, Domenico V Delfino⁵, Ngo Anh Bang⁶, Bui Huu Tai^{1

6}, Phan Van Kiem^{1

6}

Affiliations

¹ Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
² Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
³ Vietnam National University of Agriculture, Trau Quy, Gia Lam, Hanoi, 10072, Vietnam.
⁴ National Institute of Medicinal Materials, 3B Quang Trung, Hoan Kiem, 10072, Vietnam.
⁵ Master in musculoskeletal and rheumatology physiotherapy, Department of Medicine and Surgery, University of Perugia, Piazzale Severi, S. Andreadelle Fratte, 06132, Perugia, Italy.
⁶ Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam E-mail: s.

PMID: 37591796
DOI: 10.1002/cbdv.202301166

Abstract

Gnetum latifolium var. funiculare Markgr. is a medicinal plant and widely distributed in mountainous areas of Vietnam. Phytochemical investigation on the trunks of this plant afforded eight stilbene derivatives (1-8) including for new compounds (1-4). Their structures were determined based on extensive analyses of HR-ESI-MS, 1D and 2D NMR spectra. Among the isolates, compounds 1-3 showed moderate NO production inhibition in LPS-activated RAW264.7 cells with the IC₅₀ values ranging from 46.81 to 68.10 μM, compounds 4 and 6 showed weak effects with the IC₅₀ values of 96.57 and 79.46 μM, respectively, compared to that of the positive control compound, dexamethasone (IC₅₀ 14.20 μM).

Keywords: Gnetum latifolium var. funiculare; gnetumlatioside A; gnetumlatioside B; gnetumlatioside C; gnetumlatioside D.

Grants and funding

04/2022/TN/Vietnam National Foundation for Science and Technology Development